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Gene: IL12B (interleukin 12B) Homo sapiens
Symbol: IL12B
Name: interleukin 12B
Description: Exhibits identical protein binding activity; interleukin-12 alpha subunit binding activity; and protein heterodimerization activity. Contributes to cytokine activity; growth factor activity; and interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of lymphocyte proliferation; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of cytokine production. Localizes to interleukin-12 complex and interleukin-23 complex. Implicated in asthma; chronic obstructive pulmonary disease; primary immunodeficiency disease; and salmonellosis. Biomarker of anogenital venereal wart.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLMF; CLMF p40; CLMF2; cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; IL-12B; IL12, subunit p40; IMD28; IMD29; interleukin 12, p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; interleukin-12 subunit beta; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF2
Mus musculus (house mouse) : Il12b (interleukin 12b)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il12b (interleukin 12B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il12b (interleukin 12B)
Pan paniscus (bonobo/pygmy chimpanzee) : IL12B (interleukin 12B)
Canis lupus familiaris (dog) : IL12B (interleukin 12B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il12b (interleukin 12B)
Sus scrofa (pig) : IL12B (interleukin 12B)
Chlorocebus sabaeus (African green monkey) : IL12B (interleukin 12B)
Heterocephalus glaber (naked mole-rat) : Il12b (interleukin 12B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5159,314,780 - 159,330,487 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl5159,314,783 - 159,330,887 (-)EnsemblGRCh38hg38GRCh38
GRCh385159,314,780 - 159,330,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375158,741,791 - 158,757,481 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365158,674,369 - 158,690,059 (-)NCBINCBI36hg18NCBI36
Build 345158,674,368 - 158,690,059NCBI
Celera5154,772,647 - 154,788,337 (-)NCBI
Cytogenetic Map5q33.3NCBI
HuRef5153,836,180 - 153,851,870 (-)NCBIHuRef
CHM1_15158,174,226 - 158,189,916 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL12B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353629
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.