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Gene: EPHB4 (EPH receptor B4) Homo sapiens
Symbol: EPHB4
Name: EPH receptor B4
Description: Exhibits ephrin receptor activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; ephrin receptor signaling pathway; and protein autophosphorylation. Localizes to integral component of plasma membrane. Implicated in hereditary lymphedema.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMAVM2; ephrin receptor EphB4; ephrin type-B receptor 4; hepatoma transmembrane kinase; HFASD; HTK; LMPHM7; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11
Mus musculus (house mouse) : Ephb4 (Eph receptor B4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ephb4 (EPH receptor B4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ephb4 (EPH receptor B4)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHB4 (EPH receptor B4)
Canis lupus familiaris (dog) : EPHB4 (EPH receptor B4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ephb4 (EPH receptor B4)
Sus scrofa (pig) : EPHB4 (EPH receptor B4)
Chlorocebus sabaeus (African green monkey) : EPHB4 (EPH receptor B4)
Heterocephalus glaber (naked mole-rat) : Ephb4 (EPH receptor B4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl7100,802,565 - 100,827,523 (-)EnsemblGRCh38hg38GRCh38
GRCh387100,802,565 - 100,827,523 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,400,187 - 100,425,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,238,123 - 100,263,079 (-)NCBINCBI36hg18NCBI36
Build 347100,044,837 - 100,069,794NCBI
Celera795,130,741 - 95,155,701 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,030,927 - 95,055,371 (-)NCBIHuRef
CHM1_17100,330,777 - 100,355,761 (-)NCBICHM1_1
CRA_TCAGchr7v2799,759,792 - 99,784,748 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on EPHB4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353692
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.