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Gene: PGK1 (phosphoglycerate kinase 1) Homo sapiens
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Symbol: PGK1
Name: phosphoglycerate kinase 1
Description: The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell migration-inducing gene 10 protein; epididymis secretory sperm binding protein Li 68p; HEL-S-68p; MGC117307; MGC142128; MGC8947; MIG10; PGKA; primer recognition protein 2; PRP 2
Orthologs:
Mus musculus (house mouse) : Pgk1 (phosphoglycerate kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pgk1 (phosphoglycerate kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pgk1 (phosphoglycerate kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PGK1 (phosphoglycerate kinase 1)
Canis lupus familiaris (dog) : PGK1 (phosphoglycerate kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pgk1 (phosphoglycerate kinase 1)
Sus scrofa (pig) : PGK1 (phosphoglycerate kinase 1)
more info ...
Related Pseudogenes: PGK1P1   PGK1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X78,104,169 - 78,126,827 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X77,359,666 - 77,382,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,246,425 - 77,268,980 (+)NCBINCBI36hg18NCBI36
Build 34X77,165,913 - 77,188,467NCBI
CeleraX77,600,747 - 77,623,405 (+)NCBI
Cytogenetic MapXq21.1NCBI
HuRefX70,945,945 - 70,968,603 (+)NCBIHuRef
CHM1_1X77,252,363 - 77,275,021 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PGK1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353723
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.