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Gene: DERL3 (derlin 3) Homo sapiens
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Symbol: DERL3
Name: derlin 3
Description: Predicted to have misfolded protein binding activity and ubiquitin-specific protease binding activity. Involved in cellular protein metabolic process; endoplasmic reticulum unfolded protein response; and negative regulation of retrograde protein transport, ER to cytosol. Localizes to the integral component of endoplasmic reticulum membrane. Colocalizes with the signal recognition particle and signal recognition particle receptor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C22orf14; degradation in endoplasmic reticulum protein 3; Der1-like domain family, member 3; der1-like protein 3; derlin-3; DERtrin 3; DERtrin-3; IZP6; LLN2; MGC71803
Orthologs:
Mus musculus (house mouse) : Derl3 (Der1-like domain family, member 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Derl3 (derlin 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Derl3 (derlin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DERL3 (derlin 3)
Canis lupus familiaris (dog) : DERL3 (derlin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Derl3 (derlin 3)
Sus scrofa (pig) : DERL3 (derlin 3)
Chlorocebus sabaeus (African green monkey) : DERL3 (derlin 3)
Heterocephalus glaber (naked mole-rat) : Derl3 (derlin 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2223,834,503 - 23,839,128 (-)Ensembl
GRCh382223,834,498 - 23,839,348 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,176,690 - 24,181,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,506,690 - 22,511,201 (-)NCBINCBI36hg18NCBI36
Build 342222,501,245 - 22,505,755NCBI
Celera228,015,749 - 8,020,256 (-)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,164,611 - 7,169,120 (-)NCBIHuRef
CHM1_12224,188,905 - 24,193,409 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DERL3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353725
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.