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Gene: FOXO4 (forkhead box O4) Homo sapiens
Symbol: FOXO4
Name: forkhead box O4
CRRD ID: 1353756
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and identical protein binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of cell cycle; and positive regulation of cell cycle arrest. Localizes to cytosol and nuclear speck.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AFX; AFX1; fork head domain transcription factor AFX1; forkhead box protein O4; MGC120490; MLLT7; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), translocated to, 7; translocated to, 7
Mus musculus (house mouse) : Foxo4 (forkhead box O4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Foxo4 (forkhead box O4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxo4 (forkhead box O4)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXO4 (forkhead box O4)
Canis lupus familiaris (dog) : FOXO4 (forkhead box O4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxo4 (forkhead box O4)
Sus scrofa (pig) : FOXO4 (forkhead box O4)
Chlorocebus sabaeus (African green monkey) : FOXO4 (forkhead box O4)
Heterocephalus glaber (naked mole-rat) : Foxo4 (forkhead box O4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX71,095,851 - 71,103,532 (+)EnsemblGRCh38hg38GRCh38
GRCh38X71,095,851 - 71,103,534 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X70,315,999 - 70,323,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,232,751 - 70,240,109 (+)NCBINCBI36hg18NCBI36
Build 34X70,099,230 - 70,106,405NCBI
CeleraX70,670,001 - 70,677,287 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,135,718 - 64,143,103 (+)NCBIHuRef
CHM1_1X70,208,338 - 70,215,723 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FOXO4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353756
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.