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Gene: PKD2 (polycystin 2, transient receptor potential cation channel) Homo sapiens
Symbol: PKD2
Name: polycystin 2, transient receptor potential cation channel
Description: Exhibits several functions, including HLH domain binding activity; cation channel activity; and ion channel binding activity. Contributes to calcium channel activity. Involved in several processes, including inorganic cation transmembrane transport; kidney development; and protein tetramerization. Localizes to several cellular components, including the basal cortex; integral component of endoplasmic reticulum membrane; and microtubule cytoskeleton. Colocalizes with the filamentous actin. Implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APKD2; autosomal dominant polycystic kidney disease type II protein; MGC138466; MGC138468; Pc-2; PC2; PKD4; polycystic kidney disease 2 (autosomal dominant); polycystic kidney disease 2 protein; polycystin-2; polycystwin; R48321; transient receptor potential cation channel subfamily P member 2; transient receptor potential cation channel, subfamily P, member 2; TRPP2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: PKD2 (GeneID: 5311) and PRKD2 (GeneID: 25865) share the PKD2 symbol/alias in common. PKD2 is a widely used alternative name for protein kinase D2 (PRKD2), which can be confused with the official symbol for PKD2/polycystin-2/polycystic kidney disease 2. [19 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38488,007,635 - 88,077,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37488,928,799 - 88,998,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,147,844 - 89,217,953 (+)NCBINCBI36hg18NCBI36
Build 34489,285,998 - 89,356,107NCBI
Celera486,220,746 - 86,290,863 (+)NCBI
Cytogenetic Map4q22.1NCBI
HuRef484,675,256 - 84,745,398 (+)NCBIHuRef
CHM1_1488,905,594 - 88,975,728 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PKD2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353787
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.