Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: AKR1C2 (aldo-keto reductase family 1 member C2) Homo sapiens
Symbol: AKR1C2
Name: aldo-keto reductase family 1 member C2
Description: Exhibits bile acid binding activity and oxidoreductase activity. Involved in several processes, including cellular response to hormone stimulus; glycoside metabolic process; and positive regulation of protein kinase B signaling. Predicted to localize to the cytosol. Implicated in 46 XY gonadal dysgenesis. Biomarker of obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-alpha hydroxysteroid dehydrogenase, type III; 3-alpha-HSD3; AKR1C-pseudo; aldo-keto reductase family 1, member C2; BABP; bile acid binding protein; chlordecone reductase homolog HAKRD; DD; DD-2; DD/BABP; DD2; DDH2; dihydrodiol dehydrogenase 2; dihydrodiol dehydrogenase/bile acid-binding protein; FLJ53800; HAKRD; HBAB; MCDR2; pseudo-chlordecone reductase; SRXY8; TDD; testicular 17,20-desmolase deficiency; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II dihydrodiol dehydrogenase; type III 3-alpha-hydroxysteroid dehydrogenase
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38104,987,775 - 5,018,033 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37105,029,967 - 5,060,225 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,021,965 - 5,050,207 (-)NCBINCBI36hg18NCBI36
Build 34105,021,965 - 5,050,207NCBI
Celera104,972,245 - 5,000,184 (-)NCBI
Cytogenetic Map10p15.1NCBI
HuRef104,920,321 - 4,955,422 (+)NCBIHuRef
CHM1_1105,030,308 - 5,060,576 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AKR1C2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353901
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.