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Gene: AKR1C2 (aldo-keto reductase family 1 member C2) Homo sapiens
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Symbol: AKR1C2
Name: aldo-keto reductase family 1 member C2
Description: Exhibits bile acid binding activity and oxidoreductase activity. Involved in several processes, including cellular response to hormone stimulus; glycoside metabolic process; and positive regulation of protein kinase B signaling. Predicted to localize to the cytosol. Implicated in 46 XY gonadal dysgenesis. Biomarker of obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-alpha hydroxysteroid dehydrogenase, type III; 3-alpha-HSD3; AKR1C-pseudo; aldo-keto reductase family 1, member C2; BABP; bile acid binding protein; chlordecone reductase homolog HAKRD; DD; DD-2; DD/BABP; DD2; DDH2; dihydrodiol dehydrogenase 2; dihydrodiol dehydrogenase/bile acid-binding protein; FLJ53800; HAKRD; HBAB; MCDR2; pseudo-chlordecone reductase; SRXY8; TDD; testicular 17,20-desmolase deficiency; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II dihydrodiol dehydrogenase; type III 3-alpha-hydroxysteroid dehydrogenase
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38104,987,775 - 5,018,033 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37105,029,967 - 5,060,225 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,021,965 - 5,050,207 (-)NCBINCBI36hg18NCBI36
Build 34105,021,965 - 5,050,207NCBI
Celera104,972,245 - 5,000,184 (-)NCBI
Cytogenetic Map10p15.1NCBI
HuRef104,920,321 - 4,955,422 (+)NCBIHuRef
CHM1_1105,030,308 - 5,060,576 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
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miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AKR1C2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353901
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.