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Gene: OGG1 (8-oxoguanine DNA glycosylase) Homo sapiens
Symbol: OGG1
Name: 8-oxoguanine DNA glycosylase
Description: Exhibits oxidized purine DNA binding activity. Involved in several processes, including nucleotide-excision repair, DNA incision; regulation of nucleobase-containing compound metabolic process; and response to oxidative stress. Localizes to the nuclear matrix; nuclear speck; and protein-containing complex. Implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); endocrine gland cancer (multiple); and eye disease (multiple). Biomarker of several diseases, including angiomyolipoma; basal cell carcinoma; head and neck squamous cell carcinoma; progressive supranuclear palsy; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 8-hydroxyguanine DNA glycosylase; AP lyase; DNA-apurinic or apyrimidinic site lyase; HMMH; HOGG1; MUTM; N-glycosylase/DNA lyase; OGG1 type 1f; OGH1
Mus musculus (house mouse) : Ogg1 (8-oxoguanine DNA-glycosylase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ogg1 (8-oxoguanine DNA glycosylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ogg1 (8-oxoguanine DNA glycosylase)
Pan paniscus (bonobo/pygmy chimpanzee) : OGG1 (8-oxoguanine DNA glycosylase)
Canis lupus familiaris (dog) : OGG1 (8-oxoguanine DNA glycosylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ogg1 (8-oxoguanine DNA glycosylase)
Sus scrofa (pig) : OGG1 (8-oxoguanine DNA glycosylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl39,749,944 - 9,788,219 (+)Ensembl
GRCh3839,749,944 - 9,788,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3739,791,628 - 9,829,468 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3639,765,705 - 9,783,342 (+)NCBINCBI36hg18NCBI36
Build 3439,766,653 - 9,783,311NCBI
Celera39,726,330 - 9,743,054 (+)NCBI
Cytogenetic Map3p25.3NCBI
HuRef39,727,975 - 9,744,701 (+)NCBIHuRef
CHM1_139,741,823 - 9,758,548 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on OGG1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353911
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.