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Gene: PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3) Homo sapiens
Symbol: PIK3R3
Name: phosphoinositide-3-kinase regulatory subunit 3
Description: Exhibits phosphotyrosine residue binding activity. Involved in cell migration involved in sprouting angiogenesis; positive regulation of macromolecule metabolic process; and protein kinase B signaling. Predicted to localize to the phosphatidylinositol 3-kinase complex. Implicated in colon adenocarcinoma. Biomarker of malignant glioma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 100% homology to SWISS-PROT Q92569; DKFZp686P05226; FLJ41892; p55; p55-GAMMA; p55PIK; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); phosphoinositide-3-kinase regulatory subunit gamma; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma); phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38146,040,140 - 46,174,901 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37146,505,812 - 46,642,167 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,278,399 - 46,370,901 (-)NCBINCBI36hg18NCBI36
Build 34146,217,832 - 46,310,334NCBI
Celera144,793,099 - 44,886,009 (-)NCBI
Cytogenetic Map1p34.1NCBI
HuRef144,620,825 - 44,713,687 (-)NCBIHuRef
CHM1_1146,622,976 - 46,759,270 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PIK3R3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353925
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.