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Gene: NTRK3 (neurotrophic receptor tyrosine kinase 3) Homo sapiens
Symbol: NTRK3
Name: neurotrophic receptor tyrosine kinase 3
Description: Exhibits neurotrophin receptor activity and p53 binding activity. Involved in several processes, including activation of GTPase activity; positive regulation of actin cytoskeleton reorganization; and regulation of protein phosphorylation. Localizes to receptor complex. Implicated in pancreatic cancer. Biomarker of pancreatic ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; gp145(trkC); GP145-TrkC; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin 3 receptor; neurotrophin 3 receptor truncated isoform; NT-3 growth factor receptor; trk-C; TRKC; trkC tyrosine kinase; tyrosine kinase receptor C
Mus musculus (house mouse) : Ntrk3 (neurotrophic tyrosine kinase, receptor, type 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ntrk3 (neurotrophic receptor tyrosine kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ntrk3 (neurotrophic receptor tyrosine kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NTRK3 (neurotrophic receptor tyrosine kinase 3)
Canis lupus familiaris (dog) : NTRK3 (neurotrophic receptor tyrosine kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ntrk3 (neurotrophic receptor tyrosine kinase 3)
Sus scrofa (pig) : NTRK3 (neurotrophic receptor tyrosine kinase 3)
Chlorocebus sabaeus (African green monkey) : NTRK3 (neurotrophic receptor tyrosine kinase 3)
Heterocephalus glaber (naked mole-rat) : Ntrk3 (neurotrophic receptor tyrosine kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1587,859,751 - 88,256,768 (-)EnsemblGRCh38hg38GRCh38
GRCh381587,859,749 - 88,256,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371588,419,948 - 88,800,026 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361586,220,992 - 86,600,665 (-)NCBINCBI36hg18NCBI36
Build 341586,220,991 - 86,600,665NCBI
Celera1564,821,267 - 65,200,916 (-)NCBI
Cytogenetic Map15q25.3NCBI
HuRef1564,532,241 - 64,911,404 (-)NCBIHuRef
CHM1_11588,261,800 - 88,641,816 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NTRK3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354062
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.