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Gene: EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3) Homo sapiens
Symbol: EIF2AK3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Description: Exhibits eukaryotic translation initiation factor 2alpha kinase activity; identical protein binding activity; and protein phosphatase binding activity. Involved in several processes, including cellular response to starvation; positive regulation of vascular endothelial growth factor production; and protein phosphorylation. Localizes to the membrane. Implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp781H1925; eukaryotic translation initiation factor 2-alpha kinase 3; heme-regulated EIF2-alpha kinase; HRI; hsPEK; pancreatic EIF2-alpha kinase; PEK; PERK; PRKR-like endoplasmic reticulum kinase; truncated eukaryotic translation initiation factor 2 alpha kinase 3; WRS
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl288,556,741 - 88,627,464 (-)EnsemblGRCh38hg38GRCh38
GRCh38288,556,740 - 88,627,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37288,856,259 - 88,927,094 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36288,637,374 - 88,708,109 (-)NCBINCBI36hg18NCBI36
Build 34288,695,522 - 88,766,221NCBI
Celera287,859,255 - 87,930,028 (+)NCBI
Cytogenetic Map2p11.2NCBI
HuRef287,778,073 - 87,848,926 (-)NCBIHuRef
CHM1_1288,785,815 - 88,856,644 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EIF2AK3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354090
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.