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Gene: SMYD2 (SET and MYND domain containing 2) Homo sapiens
Symbol: SMYD2
Name: SET and MYND domain containing 2
CRRD ID: 1354091
Description: Exhibits p53 binding activity and protein-lysine N-methyltransferase activity. Involved in negative regulation of transcription by RNA polymerase II; peptidyl-lysine monomethylation; and regulation of DNA damage response, signal transduction by p53 class mediator. Localizes to cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: histone methyltransferase SMYD2; HSKM-B; KMT3C; lysine N-methyltransferase 3C; MGC119305; N-lysine methyltransferase SMYD2; SET and MYND domain-containing protein 2; zinc finger, MYND domain containing 14; ZMYND14
Mus musculus (house mouse) : Smyd2 (SET and MYND domain containing 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smyd2 (SET and MYND domain containing 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smyd2 (SET and MYND domain containing 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SMYD2 (SET and MYND domain containing 2)
Canis lupus familiaris (dog) : SMYD2 (SET and MYND domain containing 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smyd2 (SET and MYND domain containing 2)
Sus scrofa (pig) : SMYD2 (SET and MYND domain containing 2)
Chlorocebus sabaeus (African green monkey) : SMYD2 (SET and MYND domain containing 2)
Heterocephalus glaber (naked mole-rat) : Smyd2 (SET and MYND domain containing 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1214,281,102 - 214,337,131 (+)EnsemblGRCh38hg38GRCh38
GRCh381214,281,159 - 214,337,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371214,454,565 - 214,510,477 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,521,199 - 212,577,097 (+)NCBINCBI36hg18NCBI36
Build 341210,842,970 - 210,898,868NCBI
Celera1187,677,508 - 187,733,362 (+)NCBI
Cytogenetic Map1q32.3NCBI
HuRef1185,129,703 - 185,185,600 (+)NCBIHuRef
CHM1_11215,726,941 - 215,782,851 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SMYD2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354091
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.