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Gene: MAPKAPK5 (MAPK activated protein kinase 5) Homo sapiens
Symbol: MAPKAPK5
Name: MAPK activated protein kinase 5
Description: Exhibits p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA metabolic process; protein autophosphorylation; and stress-induced premature senescence. Localizes to cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; mitogen-activated protein kinase-activated protein kinase 5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK
Mus musculus (house mouse) : Mapkapk5 (MAP kinase-activated protein kinase 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mapkapk5 (MAPK activated protein kinase 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapkapk5 (MAPK activated protein kinase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPKAPK5 (MAPK activated protein kinase 5)
Canis lupus familiaris (dog) : MAPKAPK5 (MAPK activated protein kinase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapkapk5 (MAPK activated protein kinase 5)
Sus scrofa (pig) : MAPKAPK5 (MAPK activated protein kinase 5)
Chlorocebus sabaeus (African green monkey) : MAPKAPK5 (MAPK activated protein kinase 5)
Heterocephalus glaber (naked mole-rat) : Mapkapk5 (MAPK activated protein kinase 5)
more info ...
Related Pseudogenes: MAPKAPK5P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl12111,842,228 - 111,902,222 (+)EnsemblGRCh38hg38GRCh38
GRCh3812111,842,228 - 111,902,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712112,280,032 - 112,331,228 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,764,662 - 110,815,611 (+)NCBINCBI36hg18NCBI36
Build 3412110,742,998 - 110,793,947NCBI
Celera12111,905,742 - 111,956,689 (+)NCBI
Cytogenetic Map12q24.12-q24.13NCBI
HuRef12109,293,372 - 109,344,645 (+)NCBIHuRef
CHM1_112112,247,967 - 112,299,159 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MAPKAPK5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354160
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.