Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: DNMT1 (DNA methyltransferase 1) Homo sapiens
Analyze
Symbol: DNMT1
Name: DNA methyltransferase 1
Description: Exhibits DNA (cytosine-5-)-methyltransferase activity; DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including maintenance of DNA methylation; regulation of chromatin organization; and regulation of gene expression. Localizes to the nucleus. Implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; and hereditary sensory neuropathy type 1E. Biomarker of several diseases, including autoimmune hypersensitivity disease (multiple); endometriosis (multiple); lung cancer (multiple); myeloid leukemia (multiple); and pancreatic ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADCADN; AIM; CXXC finger protein 9; CXXC-type zinc finger protein 9; CXXC9; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; DNMT; FLJ16293; HSN1E; m.HsaI; MCMT; MGC104992
Orthologs:
Mus musculus (house mouse) : Dnmt1 (DNA methyltransferase (cytosine-5) 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnmt1 (DNA methyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnmt1 (DNA methyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DNMT1 (DNA methyltransferase 1)
Canis lupus familiaris (dog) : DNMT1 (DNA methyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnmt1 (DNA methyltransferase 1)
Sus scrofa (pig) : DNMT1 (DNA methyltransferase 1)
Chlorocebus sabaeus (green monkey) : DNMT1 (DNA methyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Dnmt1 (DNA methyltransferase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1910,133,345 - 10,231,286 (-)Ensembl
GRCh381910,133,346 - 10,194,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,244,021 - 10,305,783 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,105,022 - 10,166,811 (-)NCBINCBI36hg18NCBI36
Build 341910,105,022 - 10,166,811NCBI
Celera1910,139,454 - 10,201,147 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,824,670 - 9,886,268 (-)NCBIHuRef
CHM1_11910,244,305 - 10,306,077 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DNMT1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354178
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.