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Gene: SLC7A5 (solute carrier family 7 member 5) Homo sapiens
Symbol: SLC7A5
Name: solute carrier family 7 member 5
Description: Exhibits L-leucine transmembrane transporter activity and L-tryptophan transmembrane transporter activity. Involved in L-tryptophan transmembrane transport. Localizes to several cellular components, including the amino acid transport complex; cytosol; and integral component of membrane; PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-chloro-2,4-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4F2 LC; 4F2 light chain; 4F2LC; CD98; CD98 light chain; D16S469E; E16; hLAT1; integral membrane protein E16; L-type amino acid transporter 1; large neutral amino acids transporter 1; large neutral amino acids transporter small subunit 1; LAT1; MPE16; sodium-independent neutral amino acid transporter LAT1; solute carrier family 7 (amino acid transporter light chain, L system), member 5; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; y+ system cationic amino acid transporter
Mus musculus (house mouse) : Slc7a5 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc7a5 (solute carrier family 7 member 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc7a5 (solute carrier family 7 member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC7A5 (solute carrier family 7 member 5)
Canis lupus familiaris (dog) : SLC7A5 (solute carrier family 7 member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc7a5 (solute carrier family 7 member 5)
Sus scrofa (pig) : SLC7A5 (solute carrier family 7 member 5)
more info ...
Related Pseudogenes: SLC7A5P1   SLC7A5P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381687,830,022 - 87,869,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371687,863,629 - 87,903,100 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361686,421,130 - 86,460,601 (-)NCBINCBI36hg18NCBI36
Build 341686,421,130 - 86,460,601NCBI
Celera1672,160,934 - 72,200,417 (-)NCBI
Cytogenetic Map16q24.2NCBI
HuRef1673,604,119 - 73,643,626 (-)NCBIHuRef
CHM1_11689,274,981 - 89,314,543 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLC7A5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354186
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.