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Gene: SLC7A5 (solute carrier family 7 member 5) Homo sapiens
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Symbol: SLC7A5
Name: solute carrier family 7 member 5
Description: Exhibits L-leucine transmembrane transporter activity and L-tryptophan transmembrane transporter activity. Involved in L-tryptophan transmembrane transport. Localizes to several cellular components, including the amino acid transport complex; cytosol; and integral component of membrane; PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-chloro-2,4-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4F2 LC; 4F2 light chain; 4F2LC; CD98; CD98 light chain; D16S469E; E16; hLAT1; integral membrane protein E16; L-type amino acid transporter 1; large neutral amino acids transporter 1; large neutral amino acids transporter small subunit 1; LAT1; MPE16; sodium-independent neutral amino acid transporter LAT1; solute carrier family 7 (amino acid transporter light chain, L system), member 5; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; y+ system cationic amino acid transporter
Orthologs:
Mus musculus (house mouse) : Slc7a5 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc7a5 (solute carrier family 7 member 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc7a5 (solute carrier family 7 member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC7A5 (solute carrier family 7 member 5)
Canis lupus familiaris (dog) : SLC7A5 (solute carrier family 7 member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc7a5 (solute carrier family 7 member 5)
Sus scrofa (pig) : SLC7A5 (solute carrier family 7 member 5)
more info ...
Related Pseudogenes: SLC7A5P1   SLC7A5P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381687,830,022 - 87,869,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371687,863,629 - 87,903,100 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361686,421,130 - 86,460,601 (-)NCBINCBI36hg18NCBI36
Build 341686,421,130 - 86,460,601NCBI
Celera1672,160,934 - 72,200,417 (-)NCBI
Cytogenetic Map16q24.2NCBI
HuRef1673,604,119 - 73,643,626 (-)NCBIHuRef
CHM1_11689,274,981 - 89,314,543 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC7A5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354186
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.