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Gene: MIR138-1 (microRNA 138-1) Homo sapiens
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Symbol: MIR138-1
Name: microRNA 138-1
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-138-1; MIRN138-1
Orthologs:
Mus musculus (house mouse) : Mir138-1 (microRNA 138-1)  MGI
Rattus norvegicus (Norway rat) : Mir138-1 (microRNA 138-1)  Alliance
Canis lupus familiaris (dog) : MIR138A (microRNA mir-138a)
Sus scrofa (pig) : MIR138 (microRNA mir-138)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38344,114,212 - 44,114,310 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37344,155,704 - 44,155,802 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36344,130,707 - 44,130,805 (+)NCBINCBI36hg18NCBI36
Celera344,093,960 - 44,094,058 (+)NCBI
Cytogenetic Map3p21.32NCBI
CHM1_1344,105,818 - 44,105,916 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
 
More on MIR138-1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354224
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.