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Gene: SSX1 (SSX family member 1) Homo sapiens
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Symbol: SSX1
Name: SSX family member 1
Description: The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cancer/testis antigen 5.1; cancer/testis antigen family 5, member 1; CT5.1; MGC150425; MGC5162; sarcoma, synovial, X-chromosome-related 1; SSRC; synovial sarcoma, X breakpoint 1
Orthologs:
Mus musculus (house mouse) : Ssxb5 (synovial sarcoma, X member B5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ssx1 (SSX family member 1)  Alliance
more info ...
Related Pseudogenes: SSX8P   SSXP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,255,317 - 48,267,444 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X48,114,752 - 48,126,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,999,741 - 48,011,823 (+)NCBINCBI36hg18NCBI36
Build 34X47,871,050 - 47,883,133NCBI
Cytogenetic MapXp11.23NCBI
HuRefX45,814,294 - 45,837,908 (+)NCBIHuRef
CHM1_1X48,146,383 - 48,158,691 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SSX1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354257
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.