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Gene: NXF3 (nuclear RNA export factor 3) Homo sapiens
Symbol: NXF3
Name: nuclear RNA export factor 3
Description: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: TAP-like protein 3; TAPL-3
Mus musculus (house mouse) : Nxf3 (nuclear RNA export factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nxf3 (nuclear RNA export factor 3)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : NXF3 (nuclear RNA export factor 3)
Canis lupus familiaris (dog) : NXF3 (nuclear RNA export factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nxf3 (nuclear RNA export factor 3)
Sus scrofa (pig) : LOC102164431 (nuclear RNA export factor 3-like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X103,075,821 - 103,093,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X102,330,749 - 102,348,022 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X102,217,405 - 102,234,678 (-)NCBINCBI36hg18NCBI36
Build 34X102,136,896 - 102,154,167NCBI
CeleraX102,769,795 - 102,787,069 (-)NCBI
Cytogenetic MapXq22.1NCBI
HuRefX91,994,756 - 92,011,809 (-)NCBIHuRef
CHM1_1X102,223,442 - 102,240,732 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NXF3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354288
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.