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Gene: NXF3 (nuclear RNA export factor 3) Homo sapiens
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Symbol: NXF3
Name: nuclear RNA export factor 3
Description: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: TAP-like protein 3; TAPL-3
Orthologs:
Mus musculus (house mouse) : Nxf3 (nuclear RNA export factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nxf3 (nuclear RNA export factor 3)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : NXF3 (nuclear RNA export factor 3)
Canis lupus familiaris (dog) : NXF3 (nuclear RNA export factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nxf3 (nuclear RNA export factor 3)
Sus scrofa (pig) : LOC102164431 (nuclear RNA export factor 3-like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X103,075,821 - 103,093,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X102,330,749 - 102,348,022 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X102,217,405 - 102,234,678 (-)NCBINCBI36hg18NCBI36
Build 34X102,136,896 - 102,154,167NCBI
CeleraX102,769,795 - 102,787,069 (-)NCBI
Cytogenetic MapXq22.1NCBI
HuRefX91,994,756 - 92,011,809 (-)NCBIHuRef
CHM1_1X102,223,442 - 102,240,732 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on NXF3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354288
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.