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Gene: HEY2 (hes related family bHLH transcription factor with YRPW motif 2) Homo sapiens
Symbol: HEY2
Name: hes related family bHLH transcription factor with YRPW motif 2
CRRD ID: 1354369
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and histone deacetylase binding activity. Involved in negative regulation of transcription initiation from RNA polymerase II promoter; negative regulation of transcription regulatory region DNA binding activity; and vascular associated smooth muscle cell development. Localizes to transcription repressor complex. Colocalizes with Sin3 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHb32; cardiovascular basic helix-loop-helix factor 1; cardiovascular helix-loop-helix factor 1; CHF1; class B basic helix-loop-helix protein 32; GRIDLOCK; GRL; hairy and enhancer of split-related protein 2; hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif 2; hairy/enhancer-of-split related with YRPW motif protein 2; hCHF1; HERP1; hes-related family bHLH transcription factor with YRPW motif 2; HES-related repressor protein 1; HES-related repressor protein 2; HESR-2; HESR2; hHRT2; HRT-2; HRT2; MGC10720; protein gridlock homolog
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl6125,747,664 - 125,761,269 (+)EnsemblGRCh38hg38GRCh38
GRCh386125,747,639 - 125,762,243 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376126,066,211 - 126,082,415 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366126,112,425 - 126,124,108 (+)NCBINCBI36hg18NCBI36
Build 346126,112,565 - 126,124,110NCBI
Celera6126,813,087 - 126,824,769 (+)NCBI
Cytogenetic Map6q22.31NCBI
HuRef6123,645,968 - 123,657,653 (+)NCBIHuRef
CHM1_16126,334,804 - 126,346,479 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HEY2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354369
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.