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Gene: RAB27A (RAB27A, member RAS oncogene family) Homo sapiens
Symbol: RAB27A
Name: RAB27A, member RAS oncogene family
Description: Exhibits GDP binding activity and GTP binding activity. Involved in several processes, including complement-dependent cytotoxicity; exosomal secretion; and regulation of vesicle-mediated transport. Localizes to the cytoplasmic vesicle; dendrite; and lysosome. Implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GS2; GTP-binding protein Ram; HsT18676; MGC117246; mutant Ras-related protein Rab-27A; rab-27; RAB27; RAM; ras-related protein Rab-27A
Mus musculus (house mouse) : Rab27a (RAB27A, member RAS oncogene family)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rab27a (RAB27A, member RAS oncogene family)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rab27a (RAB27A, member RAS oncogene family)
Pan paniscus (bonobo/pygmy chimpanzee) : RAB27A (RAB27A, member RAS oncogene family)
Canis lupus familiaris (dog) : RAB27A (RAB27A, member RAS oncogene family)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rab27a (RAB27A, member RAS oncogene family)
Sus scrofa (pig) : RAB27A (RAB27A, member RAS oncogene family)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381555,202,966 - 55,291,338 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371555,495,164 - 55,582,034 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361553,283,084 - 53,369,293 (-)NCBINCBI36hg18NCBI36
Build 341553,283,093 - 53,349,877NCBI
Celera1532,384,380 - 32,470,592 (-)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1532,320,428 - 32,407,649 (-)NCBIHuRef
CHM1_11555,613,105 - 55,700,081 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on RAB27A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354398
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.