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Gene: SMC3 (structural maintenance of chromosomes 3) Homo sapiens
Symbol: SMC3
Name: structural maintenance of chromosomes 3
Description: Exhibits beta-tubulin binding activity; dynein complex binding activity; and protein heterodimerization activity. Involved in several processes, including mitotic spindle assembly; regulation of DNA replication; and sister chromatid cohesion. Localizes to chromosome; mitotic spindle pole; and nuclear lumen. Implicated in Cornelia de Lange syndrome 3.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BAM; basement membrane-associated chondroitin proteoglycan; BMH; CDLS3; chondroitin sulfate proteoglycan 6 (bamacan); chromosome-associated polypeptide; CSPG6; HCAP; SMC protein 3; SMC-3; SMC3L1; structural maintenance of chromosomes protein 3
Mus musculus (house mouse) : Smc3 (structural maintenance of chromosomes 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smc3 (structural maintenance of chromosomes 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smc3 (structural maintenance of chromosomes 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SMC3 (structural maintenance of chromosomes 3)
Canis lupus familiaris (dog) : SMC3 (structural maintenance of chromosomes 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smc3 (structural maintenance of chromosomes 3)
Sus scrofa (pig) : SMC3 (structural maintenance of chromosomes 3)
Chlorocebus sabaeus (African green monkey) : SMC3 (structural maintenance of chromosomes 3)
Heterocephalus glaber (naked mole-rat) : Smc3 (structural maintenance of chromosomes 3)
more info ...
Related Pseudogenes: SMC3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10110,567,691 - 110,604,636 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl10110,567,695 - 110,606,048 (+)EnsemblGRCh38hg38GRCh38
GRCh3810110,567,695 - 110,606,048 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710112,327,449 - 112,364,392 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,317,439 - 112,354,382 (+)NCBINCBI36hg18NCBI36
Build 3410112,317,473 - 112,354,380NCBI
Celera10106,059,046 - 106,095,991 (+)NCBI
Cytogenetic Map10q25.2NCBI
HuRef10105,957,043 - 105,993,961 (+)NCBIHuRef
CHM1_110112,609,271 - 112,646,175 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SMC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354451
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.