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Gene: ONECUT2 (one cut homeobox 2) Homo sapiens
Symbol: ONECUT2
Name: one cut homeobox 2
Description: This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hepatocyte nuclear factor 6-beta; HNF-6-beta; MGC120377; MGC120378; OC-2; OC2; one cut domain family member 2; one cut domain, family member 2; onecut 2; ONECUT-2 homeodomain transcription factor; transcription factor ONECUT-2
Mus musculus (house mouse) : Onecut2 (one cut domain, family member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Onecut2 (one cut homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Onecut2 (one cut homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ONECUT2 (one cut homeobox 2)
Canis lupus familiaris (dog) : ONECUT2 (one cut homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Onecut2 (one cut homeobox 2)
Sus scrofa (pig) : ONECUT2 (one cut homeobox 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381857,435,374 - 57,491,298 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371855,102,917 - 55,158,530 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,253,915 - 53,309,528 (+)NCBINCBI36hg18NCBI36
Build 341853,253,914 - 53,295,062NCBI
Celera1851,819,929 - 51,875,634 (+)NCBI
Cytogenetic Map18q21.31NCBI
HuRef1851,813,575 - 51,869,027 (+)NCBIHuRef
CHM1_11855,098,361 - 55,153,854 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ONECUT2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354460
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.