Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: KDM6A (lysine demethylase 6A) Homo sapiens
Symbol: KDM6A
Name: lysine demethylase 6A
CRRD ID: 1354488
Description: Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone demethylase activity (H3-K27 specific). Predicted to be involved in several processes, including animal organ development; chromatin organization; and neural tube development. Localizes to MLL3/4 complex. Implicated in Kabuki syndrome; acute lymphoblastic leukemia; and esophagus squamous cell carcinoma. Biomarker of breast cancer; prostate cancer; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [histone H3]-trimethyl-L-lysine(27) demethylase 6A; bA386N14.2; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); DKFZp686A03225; histone demethylase UTX; KABUK2; lysine (K)-specific demethylase 6A; lysine-specific demethylase 6A; MGC141941; ubiquitously transcribed tetratricopeptide repeat protein X-linked; ubiquitously transcribed TPR protein on the X chromosome; ubiquitously transcribed X chromosome tetratricopeptide repeat protein; ubiquitously-transcribed TPR gene on the X chromosome; ubiquitously-transcribed TPR protein on the X chromosome; ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; UTX
Mus musculus (house mouse) : Kdm6a (lysine (K)-specific demethylase 6A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm6a (lysine demethylase 6A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm6a (lysine demethylase 6A)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM6A (lysine demethylase 6A)
Canis lupus familiaris (dog) : KDM6A (lysine demethylase 6A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm6a (lysine demethylase 6A)
Sus scrofa (pig) : KDM6A (lysine demethylase 6A)
Chlorocebus sabaeus (African green monkey) : KDM6A (lysine demethylase 6A)
Heterocephalus glaber (naked mole-rat) : Kdm6a (lysine demethylase 6A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX44,873,177 - 45,112,779 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX44,873,177 - 45,112,602 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX44,873,188 - 45,112,779 (+)EnsemblGRCh38hg38GRCh38
GRCh38X44,873,182 - 45,112,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X44,732,419 - 44,972,024 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X44,617,725 - 44,856,791 (+)NCBINCBI36hg18NCBI36
Build 34X44,489,034 - 44,728,097NCBI
CeleraX48,869,187 - 49,108,532 (+)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX42,453,849 - 42,692,064 (+)NCBIHuRef
CHM1_1X44,765,275 - 45,004,750 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KDM6A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354488
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.