Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: RPS6KA3 (ribosomal protein S6 kinase A3) Homo sapiens
Analyze
Symbol: RPS6KA3
Name: ribosomal protein S6 kinase A3
Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 90 kDa ribosomal protein S6 kinase 3; CLS; Coffin-Lowry syndrome; HU-3; insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; MAPKAPK1B; mental retardation, X-linked 19; MRX19; p90-RSK 3; p90-RSK2; p90RSK3; pp90RSK2; ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; ribosomal S6 kinase 2; RSK; RSK-2; RSK2; S6K-alpha-3; S6K-alpha3
Orthologs:
Mus musculus (house mouse) : Rps6ka3 (ribosomal protein S6 kinase polypeptide 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rps6ka3 (ribosomal protein S6 kinase A3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rps6ka3 (ribosomal protein S6 kinase A3)
Pan paniscus (bonobo/pygmy chimpanzee) : RPS6KA3 (ribosomal protein S6 kinase A3)
Canis lupus familiaris (dog) : RPS6KA3 (ribosomal protein S6 kinase A3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rps6ka3 (ribosomal protein S6 kinase A3)
Sus scrofa (pig) : RPS6KA3 (ribosomal protein S6 kinase A3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X20,149,911 - 20,267,514 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X20,168,029 - 20,285,523 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X20,077,950 - 20,194,671 (-)NCBINCBI36hg18NCBI36
Build 34X19,927,686 - 20,044,407NCBI
CeleraX24,292,410 - 24,377,495 (-)NCBI
Cytogenetic MapXp22.12NCBI
HuRefX17,910,375 - 17,994,979 (-)NCBIHuRef
CHM1_1X20,198,431 - 20,315,161 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on RPS6KA3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354498
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-23
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.