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Gene: PNPLA2 (patatin like phospholipase domain containing 2) Homo sapiens
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Symbol: PNPLA2
Name: patatin like phospholipase domain containing 2
Description: Predicted to have triglyceride lipase activity. Involved in negative regulation of sequestering of triglyceride and positive regulation of triglyceride catabolic process. Localizes to lipid droplet and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1110001C14Rik; adipose triglyceride lipase; ATGL; calcium-independent phospholipase A2; desnutrin; DKFZp667M109; FP17548; IPLA2-zeta; iPLA2zeta; mutant patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; patatin-like phospholipase domain-containing protein 2; patatin-like phospholipase domain-containing protein 2-like; PEDF-R; pigment epithelium-derived factor; transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS-2.2; TTS2; TTS2.2
Orthologs:
Mus musculus (house mouse) : Pnpla2 (patatin-like phospholipase domain containing 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pnpla2 (patatin-like phospholipase domain containing 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pnpla2 (patatin like phospholipase domain containing 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PNPLA2 (patatin like phospholipase domain containing 2)
Canis lupus familiaris (dog) : PNPLA2 (patatin like phospholipase domain containing 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pnpla2 (patatin like phospholipase domain containing 2)
Sus scrofa (pig) : PNPLA2 (patatin like phospholipase domain containing 2)
Chlorocebus sabaeus (African green monkey) : PNPLA2 (patatin like phospholipase domain containing 2)
Heterocephalus glaber (naked mole-rat) : Pnpla2 (patatin like phospholipase domain containing 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl11818,914 - 825,573 (+)EnsemblGRCh38hg38GRCh38
GRCh3811818,890 - 825,573 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711818,901 - 825,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611808,902 - 815,217 (+)NCBINCBI36hg18NCBI36
Build 3411808,901 - 815,216NCBI
Celera11885,450 - 892,225 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11634,726 - 640,840 (+)NCBIHuRef
CHM1_111817,799 - 824,534 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on PNPLA2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1354502
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.