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Gene: Pdhb (pyruvate dehydrogenase E1 subunit beta) Rattus norvegicus
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Symbol: Pdhb
Name: pyruvate dehydrogenase E1 subunit beta
Description: Exhibits pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Localizes to mitochondrion and pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC94149; PDHE1-B; pyruvate dehydrogenase (lipoamide) beta; pyruvate dehydrogenase E1 beta subunit; pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Orthologs:
Homo sapiens (human) : PDHB (pyruvate dehydrogenase E1 subunit beta)  HGNC  Alliance
Mus musculus (house mouse) : Pdhb (pyruvate dehydrogenase (lipoamide) beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdhb (pyruvate dehydrogenase E1 beta subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : PDHB (pyruvate dehydrogenase E1 subunit beta)
Canis lupus familiaris (dog) : PDHB (pyruvate dehydrogenase E1 subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdhb (pyruvate dehydrogenase E1 beta subunit)
Sus scrofa (pig) : PDHB (pyruvate dehydrogenase E1 subunit beta)
Chlorocebus sabaeus (African green monkey) : PDHB (pyruvate dehydrogenase E1 subunit beta)
Heterocephalus glaber (naked mole-rat) : Pdhb (pyruvate dehydrogenase E1 subunit beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01518,540,826 - 18,546,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,539,210 - 18,546,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,507,861 - 22,513,890 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,737,449 - 18,743,391 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11518,737,448 - 18,743,390 (+)NCBI
Celera1516,710,789 - 16,716,731 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Pdhb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1359146
Created: 2005-07-29
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.