Gene: Itch (itchy E3 ubiquitin protein ligase) Rattus norvegicus
Symbol: Itch
Name: itchy E3 ubiquitin protein ligase
Description: Predicted to have several functions, including CXCR chemokine receptor binding activity, arrestin family protein binding activity, and ligase activity; predicted to be involved in several processes, including cellular protein metabolic process, negative regulation of NF-kappaB transcription factor activity, and regulation of protein metabolic process; predicted to colocalize with the early endosome; orthologous to human ITCH (itchy E3 ubiquitin protein ligase); PARTICIPATES IN Notch signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH atrazine; bisphenol A; gentamycin.
Type: protein-coding
Also known as: E3 ubiquitin-protein ligase Itchy homolog; itch E3 ubiquitin ligase; itchy E3 ubiquitin protein ligase homolog; itchy E3 ubiquitin protein ligase homolog (mouse); itchy homolog E3 ubiquitin protein ligase; itchy homolog E3 ubiquitin protein ligase (mouse); itchy, E3 ubiquitin protein ligase
Homo sapiens (human) : ITCH (itchy E3 ubiquitin protein ligase)  HGNC  Alliance
Mus musculus (house mouse) : Itch (itchy, E3 ubiquitin protein ligase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itch (itchy E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : ITCH (itchy E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : ITCH (itchy E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itch (itchy E3 ubiquitin protein ligase)
Sus scrofa (pig) : ITCH (itchy E3 ubiquitin protein ligase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03150,660,665 - 150,752,016 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03157,055,848 - 157,117,955 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,644,315 - 145,707,190 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13145,549,936 - 145,612,812 (+)NCBI
Celera3142,396,380 - 142,459,141 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Itch
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1359556
Created: 2005-07-29
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.