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Gene: Dlst (dihydrolipoamide S-succinyltransferase) Rattus norvegicus
Symbol: Dlst
Name: dihydrolipoamide S-succinyltransferase
Description: Exhibits chaperone binding activity; dihydrolipoyllysine-residue succinyltransferase activity; and heat shock protein binding activity. Involved in 2-oxoglutarate metabolic process and NADH metabolic process. Localizes to the mitochondrion; oxoglutarate dehydrogenase complex; and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; citric acid cycle pathway; fumaric aciduria pathway; INTERACTS WITH 2,2,2-tetramine; 2,4,6-trinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2-oxoglutarate dehydrogenase complex component E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; E2; E2K; MGC95077; OGDC-E2
Homo sapiens (human) : DLST (dihydrolipoamide S-succinyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Dlst (dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlst (dihydrolipoamide S-succinyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DLST (dihydrolipoamide S-succinyltransferase)
Canis lupus familiaris (dog) : DLST (dihydrolipoamide S-succinyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlst (dihydrolipoamide S-succinyltransferase)
Sus scrofa (pig) : DLST (dihydrolipoamide S-succinyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06108,936,534 - 108,961,322 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,936,664 - 108,959,803 (+)Ensembl
Rnor_5.06116,595,654 - 116,620,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,156,751 - 109,180,537 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16109,160,220 - 109,183,992 (+)NCBI
Celera6102,581,378 - 102,605,253 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Dlst
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1359615
Created: 2005-07-29
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.