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Gene: Cd59em1Ask (CD59 molecule; CRISPR/Cas9 induced mutant1, Ask) Rattus norvegicus
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Symbol: Cd59em1Ask
Name: CD59 molecule; CRISPR/Cas9 induced mutant1, Ask
Description: The CRISPR/Cas9 genome editing system was used to generate Cd59 mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 3 of the rat Cd59 created a 11 bp-deletion (TGCAAAACAAA) in exon 3. No protein expression was detected in the blood smear of homozygous mutants.
ASSOCIATED WITH decreased erythrocyte cell number; increased red blood cell distribution width; increased susceptibility to type III hypersensitivity reaction; ASSOCIATED WITH neuromyelitis optica
Type: allele  of Cd59  
Is Marker For: Strains:   SD-Cd59em1Ask-/-  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position: No map positions available.


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Phenotype Annotations
References - curated

Genomics

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Sequence

Nucleotide Sequences

Additional Information

Nomenclature History
 
More on Cd59em1Ask
Alliance Gene
Ensembl Gene
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CRRD Object Information
CRRD ID: 13792720
Created: 2018-09-24
Species: Rattus norvegicus
Last Modified: 2018-09-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.