KLHL22 (kelch like family member 22) - Chinchilla Research Resource Database
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Gene: KLHL22 (kelch like family member 22) Sus scrofa
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Symbol: KLHL22
Name: kelch like family member 22
CRRD ID: 13909939
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); INVOLVED IN cellular response to leucine (ortholog); mitotic sister chromatid segregation (ortholog); negative regulation of autophagy (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); DiGeorge syndrome (ortholog); FOUND IN Golgi apparatus (ortholog); intercellular bridge (ortholog); lysosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: kelch-like 22; kelch-like protein 22
Orthologs:
Homo sapiens (human) : KLHL22 (kelch like family member 22)  HGNC  Alliance
Mus musculus (house mouse) : Klhl22 (kelch-like 22)  MGI  Alliance
Rattus norvegicus (Norway rat) : Klhl22 (kelch-like family member 22)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klhl22 (kelch like family member 22)
Pan paniscus (bonobo/pygmy chimpanzee) : KLHL22 (kelch like family member 22)
Canis lupus familiaris (dog) : KLHL22 (kelch like family member 22)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klhl22 (kelch like family member 22)
Chlorocebus sabaeus (African green monkey) : KLHL22 (kelch like family member 22)
Heterocephalus glaber (naked mole-rat) : Klhl22 (kelch like family member 22)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11450,773,917 - 50,809,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,334,392 - 54,451,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
KLHL22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11450,773,917 - 50,809,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,334,392 - 54,451,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2220,441,519 - 20,495,844 (-)EnsemblGRCh38hg38GRCh38
GRCh382220,441,519 - 20,497,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372220,795,806 - 20,850,170 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,125,806 - 19,180,122 (-)NCBINCBI36hg18NCBI36
Celera224,282,529 - 4,336,886 (-)NCBI
Cytogenetic Map22q11.21NCBI
HuRef224,059,895 - 4,107,538 (-)NCBIHuRef
CHM1_12220,796,082 - 20,850,455 (-)NCBICHM1_1
Klhl22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,577,485 - 17,611,246 (+)NCBI
GRCm381617,759,621 - 17,793,382 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,759,618 - 17,793,382 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,759,714 - 17,793,475 (+)NCBIGRCm37mm9NCBIm37
MGSCv361617,673,234 - 17,706,943 (+)NCBImm8
Celera1618,332,703 - 18,366,464 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.01NCBI
Klhl22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01187,646,489 - 87,718,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,677,966 - 87,718,826 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,699,112 - 90,771,253 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,179,262 - 85,220,103 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,219,855 - 85,260,693 (-)NCBI
Celera1181,962,736 - 82,003,585 (-)NCBICelera
Cytogenetic Map11q23NCBI
Klhl22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544219,010,971 - 19,051,300 (-)NCBIChiLan1.0ChiLan1.0
KLHL22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12219,126,658 - 19,174,839 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,122,875 - 19,174,842 (-)Ensemblpanpan1.1panPan2
KLHL22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2630,248,240 - 30,281,843 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12630,248,253 - 30,281,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Klhl22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366192,854,915 - 2,899,386 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL22
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl195,218,653 - 5,265,063 (+)Ensembl
ChlSab1.1195,211,732 - 5,264,953 (+)NCBI
Klhl22
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624945409,093 - 446,619 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 4 3 5 2 22 2 3 3
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: XM_021072689   ⟹   XP_020928348
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11450,773,917 - 50,809,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021072690   ⟹   XP_020928349
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11450,773,976 - 50,809,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021072691   ⟹   XP_020928350
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11450,773,922 - 50,809,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021072692   ⟹   XP_020928351
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11450,774,046 - 50,809,991 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020928348 (Get FASTA)   NCBI Sequence Viewer  
  XP_020928349 (Get FASTA)   NCBI Sequence Viewer  
  XP_020928350 (Get FASTA)   NCBI Sequence Viewer  
  XP_020928351 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein JAA74060 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020928348   ⟸   XM_021072689
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020928350   ⟸   XM_021072691
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020928349   ⟸   XM_021072690
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020928351   ⟸   XM_021072692
- Peptide Label: isoform X1
- Sequence:
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010108 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070019549 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010781 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000025581 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070032351 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011069 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000022693 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070038651 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL22 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene KLHL22 ENTREZGENE
PANTHER PTHR45632:SF5 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A4X1UQQ6_PIG UniProtKB/TrEMBL
  F1RK84_PIG UniProtKB/TrEMBL
  I3LNA7_PIG UniProtKB/TrEMBL
  M3UYW6_PIG UniProtKB/TrEMBL