PTPN11 (protein tyrosine phosphatase non-receptor type 11) - Chinchilla Research Resource Database
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Gene: PTPN11 (protein tyrosine phosphatase non-receptor type 11) Sus scrofa
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Symbol: PTPN11
Name: protein tyrosine phosphatase non-receptor type 11
CRRD ID: 13937253
Description: ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); insulin receptor substrate binding (ortholog); INVOLVED IN brain development (ortholog); cellular response to angiotensin (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenocarcinoma (ortholog); anogenital venereal wart (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: non-receptor type protein tyrosine phosphatase SHP2; tyrosine-protein phosphatase non-receptor type 11
Orthologs:
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,202,168 - 39,292,018 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,202,165 - 39,292,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,703,693 - 41,793,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
anogenital venereal wart  (ISO)
aortic valve stenosis  (ISO)
Arachnoid Cysts  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
astrocytoma  (ISO)
atrophic gastritis  (ISO)
autism spectrum disorder  (ISO)
Brain Neoplasms  (ISO)
Cafe-au-Lait Spots  (ISO)
cancer  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
Carotid Artery Injuries  (ISO)
cervical cancer  (ISO)
chondroma  (ISO)
chronic lymphocytic leukemia  (ISO)
clubfoot  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
craniosynostosis  (ISO)
Developmental Disabilities  (ISO)
dilated cardiomyopathy  (ISO)
Dwarfism  (ISO)
embryonal rhabdomyosarcoma  (ISO)
Failure to Thrive  (ISO)
Fetal Growth Retardation  (ISO)
Flatfoot  (ISO)
Funnel Chest  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
Haemophilus Infections  (ISO)
Helicobacter Infections  (ISO)
hereditary multiple exostoses  (ISO)
hiatus hernia  (ISO)
Hypertelorism  (ISO)
hypertrophic cardiomyopathy  (ISO)
influenza  (ISO)
intellectual disability  (ISO)
juvenile myelomonocytic leukemia  (ISO)
Language Development Disorders  (ISO)
leukemia  (ISO)
lung adenocarcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
metachondromatosis  (ISO)
microcephaly  (ISO)
multiple myeloma  (ISO)
Muscle Hypotonia  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
neurofibroma  (ISO)
neurofibromatosis-Noonan syndrome  (ISO)
Noonan Like Syndrome  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 3  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
Noonan syndrome with multiple lentigines 1  (ISO)
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia  (ISO)
Ollier disease  (ISO)
Osteochondroma  (ISO)
Paraproteinemias  (ISO)
plasma cell neoplasm  (ISO)
plasmacytoma  (ISO)
Pneumonia, Staphylococcal  (ISO)
ptosis  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
scoliosis  (ISO)
sensorineural hearing loss  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Telecanthus  (ISO)
tetralogy of Fallot  (ISO)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
abortive mitotic cell cycle  (IEA)
activation of MAPK activity  (IEA)
atrioventricular canal development  (IEA)
axonogenesis  (IEA)
Bergmann glial cell differentiation  (IEA)
brain development  (ISO)
cellular response to angiotensin  (ISO)
cellular response to epidermal growth factor stimulus  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cerebellar cortex formation  (IEA)
DNA damage checkpoint  (IEA)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
ERBB signaling pathway  (ISO)
face morphogenesis  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
genitalia development  (IEA)
glucose homeostasis  (IEA)
heart development  (ISO)
homeostasis of number of cells within a tissue  (IEA)
hormone metabolic process  (IEA)
hormone-mediated signaling pathway  (IEA)
inner ear development  (IEA)
integrin-mediated signaling pathway  (IEA)
intestinal epithelial cell migration  (IEA)
lipid metabolic process  (ISO)
megakaryocyte development  (IEA)
microvillus organization  (IEA)
multicellular organism growth  (IEA)
multicellular organismal reproductive process  (IEA)
negative regulation of cell adhesion mediated by integrin  (IEA)
negative regulation of chondrocyte differentiation  (IEA)
negative regulation of cortisol secretion  (IEA)
negative regulation of growth hormone secretion  (IEA)
negative regulation of hormone secretion  (ISO)
negative regulation of insulin secretion  (IEA)
neurotrophin TRK receptor signaling pathway  (IEA)
organ growth  (IEA)
peptidyl-tyrosine dephosphorylation  (IEA)
platelet formation  (IEA)
platelet-derived growth factor receptor signaling pathway  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of glucose import  (IEA)
positive regulation of hormone secretion  (IEA)
positive regulation of insulin receptor signaling pathway  (IEA)
positive regulation of interferon-beta production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of ossification  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of signal transduction  (ISO)
positive regulation of tumor necrosis factor production  (IEA)
protein dephosphorylation  (ISO)
regulation of cell adhesion mediated by integrin  (ISO)
regulation of protein export from nucleus  (IEA)
regulation of protein-containing complex assembly  (IEA)
smooth muscle cell proliferation  (ISO)
triglyceride metabolic process  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:16284184  


Genomics

Comparative Map Data
PTPN11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,202,168 - 39,292,018 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,202,165 - 39,292,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,703,693 - 41,793,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12112,418,351 - 112,509,918 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl12112,418,351 - 112,509,913 (+)EnsemblGRCh38hg38GRCh38
GRCh3812112,418,915 - 112,509,918 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712112,856,536 - 112,947,717 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,340,919 - 111,432,100 (+)NCBINCBI36hg18NCBI36
Build 3412111,319,255 - 111,410,436NCBI
Celera12112,483,686 - 112,574,781 (+)NCBI
Cytogenetic Map12q24.13NCBI
HuRef12109,868,826 - 109,960,330 (+)NCBIHuRef
CHM1_112112,825,224 - 112,916,404 (+)NCBICHM1_1
Ptpn11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,268,596 - 121,329,460 (-)NCBI
GRCm385121,130,533 - 121,191,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,130,533 - 121,191,397 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,580,542 - 121,641,406 (-)NCBIGRCm37mm9NCBIm37
MGSCv365121,391,158 - 121,451,946 (-)NCBImm8
Celera5118,220,712 - 118,281,623 (-)NCBICelera
Cytogenetic Map5FNCBI
Ptpn11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01240,895,515 - 40,955,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,895,515 - 40,955,999 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,762,630 - 42,822,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,501,886 - 36,558,055 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11236,365,273 - 36,421,443 (+)NCBI
Celera1237,029,879 - 37,089,260 (+)NCBICelera
Cytogenetic Map12q16NCBI
RH 3.4 Map12646.0RGD
Ptpn11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,934,306 - 9,035,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,934,734 - 9,031,230 (+)NCBIChiLan1.0ChiLan1.0
PTPN11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112113,412,077 - 113,503,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12113,435,669 - 113,503,762 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012110,016,364 - 110,107,462 (+)NCBIMhudiblu_PPA_v0panPan3
PTPN11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl269,989,425 - 10,067,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1269,989,218 - 10,072,245 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ptpn11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366682,602,261 - 2,687,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl11107,658,453 - 107,752,637 (+)Ensembl
ChlSab1.111107,658,495 - 107,754,457 (+)NCBI
Ptpn11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474719,721,581 - 19,813,639 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000030697   ⟹   ENSSSCP00000020527
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1439,202,169 - 39,292,018 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000040231   ⟹   ENSSSCP00000046233
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1439,202,619 - 39,291,969 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000069881   ⟹   ENSSSCP00000068049
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1439,202,168 - 39,291,984 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000082803   ⟹   ENSSSCP00000060060
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1439,202,168 - 39,285,545 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089137   ⟹   ENSSSCP00000064345
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1439,202,168 - 39,291,984 (-)Ensembl
RefSeq Acc Id: XM_013990361   ⟹   XP_013845815
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,202,165 - 39,292,038 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013990362   ⟹   XP_013845816
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,202,165 - 39,292,039 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013990364   ⟹   XP_013845818
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,202,165 - 39,292,041 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073562   ⟹   XP_020929221
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,202,165 - 39,292,039 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073563   ⟹   XP_020929222
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,202,165 - 39,292,038 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013845818   ⟸   XM_013990364
- Peptide Label: isoform X3
- UniProtKB: A0A287AQB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013845816   ⟸   XM_013990362
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020929221   ⟸   XM_021073562
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020929222   ⟸   XM_021073563
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013845815   ⟸   XM_013990361
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000020527   ⟸   ENSSSCT00000030697
RefSeq Acc Id: ENSSSCP00000046233   ⟸   ENSSSCT00000040231
RefSeq Acc Id: ENSSSCP00000064345   ⟸   ENSSSCT00000089137
RefSeq Acc Id: ENSSSCP00000068049   ⟸   ENSSSCT00000069881
RefSeq Acc Id: ENSSSCP00000060060   ⟸   ENSSSCT00000082803

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030289 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070008794 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000020527 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000046233 UniProtKB/TrEMBL
  ENSSSCP00000060060 UniProtKB/TrEMBL
  ENSSSCP00000064345 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000068049 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070014128 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030697 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000040231 UniProtKB/TrEMBL
  ENSSSCT00000069881 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000082803 UniProtKB/TrEMBL
  ENSSSCT00000089137 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070017070 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-6/11 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
KEGG Report ssc:100170851 UniProtKB/TrEMBL
NCBI Gene PTPN11 ENTREZGENE
Pfam SH2 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PIRSF Tyr-Ptase_nr_6 UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniGene Ssc.22794 ENTREZGENE
  Ssc.78458 ENTREZGENE
UniProt A0A287AQB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A480ERB4_PIG UniProtKB/TrEMBL
  A0A480LMF4_PIG UniProtKB/TrEMBL
  A0A4X1TG72_PIG UniProtKB/TrEMBL
  A0A5G2QDD3_PIG UniProtKB/TrEMBL
  A0A5G2RBQ6_PIG UniProtKB/TrEMBL
  B3VK31_PIG UniProtKB/TrEMBL
  I3L916_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91972 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN11  protein tyrosine phosphatase non-receptor type 11    protein tyrosine phosphatase, non-receptor type 11  Symbol and/or name change 5135510 APPROVED