DHX58 (DExH-box helicase 58) - Chinchilla Research Resource Database
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Gene: DHX58 (DExH-box helicase 58) Sus scrofa
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Symbol: DHX58
Name: DExH-box helicase 58
CRRD ID: 14083196
Description: ENCODES a protein that exhibits ATP binding (inferred); DNA binding (inferred); RNA helicase activity (inferred); INVOLVED IN positive regulation of type I interferon production (ortholog); regulation of innate immune response (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-dependent RNA helicase DHX58; LGP2; probable ATP-dependent RNA helicase DHX58
Orthologs:
Homo sapiens (human) : DHX58 (DExH-box helicase 58)  HGNC  Alliance
Mus musculus (house mouse) : Dhx58 (DEXH (Asp-Glu-X-His) box polypeptide 58)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dhx58 (DEXH-box helicase 58)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhx58 (DExH-box helicase 58)
Pan paniscus (bonobo/pygmy chimpanzee) : DHX58 (DExH-box helicase 58)
Canis lupus familiaris (dog) : DHX58 (DExH-box helicase 58)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhx58 (DExH-box helicase 58)
Chlorocebus sabaeus (African green monkey) : DHX58 (DExH-box helicase 58)
Heterocephalus glaber (naked mole-rat) : Dhx58 (DExH-box helicase 58)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,647,692 - 20,656,692 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,647,698 - 20,656,691 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,937,850 - 20,946,843 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:20331611  


Genomics

Comparative Map Data
DHX58
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,647,692 - 20,656,692 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,647,698 - 20,656,691 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,937,850 - 20,946,843 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DHX58
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,101,404 - 42,112,714 (-)EnsemblGRCh38hg38GRCh38
GRCh381742,101,404 - 42,112,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,253,422 - 40,264,751 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,506,948 - 37,518,277 (-)NCBINCBI36hg18NCBI36
Celera1736,908,460 - 36,919,789 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,018,500 - 36,029,831 (-)NCBIHuRef
CHM1_11740,489,197 - 40,500,526 (-)NCBICHM1_1
Dhx58
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,585,710 - 100,595,165 (-)NCBI
GRCm3811100,694,884 - 100,704,271 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,694,884 - 100,704,271 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,556,198 - 100,565,585 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611100,510,974 - 100,520,361 (-)NCBImm8
Celera11111,311,383 - 111,320,770 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.52NCBI
Dhx58
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01088,599,722 - 88,611,562 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,599,680 - 88,611,105 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,393,935 - 88,405,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,630,145 - 89,641,311 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11089,644,843 - 89,655,680 (-)NCBI
Celera1084,336,054 - 84,347,209 (-)NCBICelera
Cytogenetic Map10q31NCBI
Dhx58
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,185,510 - 16,191,719 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,186,263 - 16,191,928 (-)NCBIChiLan1.0ChiLan1.0
DHX58
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,424,444 - 15,435,588 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,424,437 - 15,435,582 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,203,216 - 15,214,559 (+)NCBIMhudiblu_PPA_v0panPan3
DHX58
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl920,787,541 - 20,795,361 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1920,787,470 - 20,795,593 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dhx58
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649016,940,776 - 16,949,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHX58
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1664,154,984 - 64,166,500 (+)Ensembl
ChlSab1.11664,154,832 - 64,166,480 (+)NCBI
Dhx58
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,787,958 - 1,793,475 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 2 3 5 21 3 3
Below cutoff 2 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018960   ⟹   ENSSSCP00000018455
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,647,692 - 20,656,692 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000033560   ⟹   ENSSSCP00000029007
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,647,908 - 20,656,673 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000035155   ⟹   ENSSSCP00000030733
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,647,908 - 20,656,665 (+)Ensembl
RefSeq Acc Id: NM_001199132   ⟹   NP_001186061
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,647,753 - 20,656,605 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005668814   ⟹   XP_005668871
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,647,705 - 20,656,691 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005668815   ⟹   XP_005668872
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,647,698 - 20,656,691 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001186061 (Get FASTA)   NCBI Sequence Viewer  
  XP_005668871 (Get FASTA)   NCBI Sequence Viewer  
  XP_005668872 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACQ73327 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005668872   ⟸   XM_005668815
- Peptide Label: isoform X2
- UniProtKB: K7GS53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005668871   ⟸   XM_005668814
- Peptide Label: isoform X1
- UniProtKB: F1S0P6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001186061   ⟸   NM_001199132
- UniProtKB: E3NZJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000030733   ⟸   ENSSSCT00000035155
RefSeq Acc Id: ENSSSCP00000018455   ⟸   ENSSSCT00000018960
RefSeq Acc Id: ENSSSCP00000029007   ⟸   ENSSSCT00000033560

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017416 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070014443 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000018455 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000029007 UniProtKB/TrEMBL
  ENSSSCP00000030733 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070023636 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018960 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000033560 UniProtKB/TrEMBL
  ENSSSCT00000035155 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070028381 UniProtKB/TrEMBL
Gene3D-CATH 2.170.150.30 UniProtKB/TrEMBL
InterPro Helicase/UvrB_N UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RIG-I_C UniProtKB/TrEMBL
  RLR_C_sf UniProtKB/TrEMBL
  RLR_CTR UniProtKB/TrEMBL
KEGG Report ssc:100524520 UniProtKB/TrEMBL
NCBI Gene DHX58 ENTREZGENE
Pfam Helicase_C UniProtKB/TrEMBL
  ResIII UniProtKB/TrEMBL
  RIG-I_C UniProtKB/TrEMBL
  RIG-I_C-RD UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  RLR_CTR UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniGene Ssc.42824 ENTREZGENE
UniProt A0A4X1U1Q9_PIG UniProtKB/TrEMBL
  A0A5K1U4K5_PIG UniProtKB/TrEMBL
  E3NZJ4 ENTREZGENE, UniProtKB/TrEMBL
  F1S0P6 ENTREZGENE, UniProtKB/TrEMBL
  K7GS53 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary K7GMB7 UniProtKB/TrEMBL
VGNC ID VGNC:87297 ENTREZGENE