PTPN22 (protein tyrosine phosphatase non-receptor type 22) - Chinchilla Research Resource Database
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Gene: PTPN22 (protein tyrosine phosphatase non-receptor type 22) Sus scrofa
Analyze
Symbol: PTPN22
Name: protein tyrosine phosphatase non-receptor type 22
CRRD ID: 14098321
Description: ENCODES a protein that exhibits phosphatase activity (ortholog); protein tyrosine kinase binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN lipopolysaccharide-mediated signaling pathway (ortholog); negative regulation of autophagy (ortholog); negative regulation of gene expression (ortholog); ASSOCIATED WITH Addison's disease (ortholog); alopecia areata (ortholog); Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: protein tyrosine phosphatase, non-receptor type 22 (lymphoid); tyrosine-protein phosphatase non-receptor type 22
Orthologs:
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4106,686,604 - 106,758,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14106,692,102 - 106,758,101 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,897,216 - 116,927,483 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to muramyl dipeptide  (IEA)
lipopolysaccharide-mediated signaling pathway  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-6 production  (IEA)
negative regulation of interleukin-8 production  (IEA)
negative regulation of JUN kinase activity  (ISO)
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IBA)
negative regulation of p38MAPK cascade  (IBA)
negative regulation of T cell activation  (IBA)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (IBA)
peptidyl-tyrosine dephosphorylation  (IBA,IEA)
phosphoanandamide dephosphorylation  (IEA)
positive regulation of CD8-positive, alpha-beta T cell proliferation  (IBA)
positive regulation of defense response to virus by host  (IBA)
positive regulation of ERK1 and ERK2 cascade  (IBA)
positive regulation of gene expression  (ISO)
positive regulation of granzyme B production  (IBA)
positive regulation of interferon-alpha production  (IEA)
positive regulation of interferon-beta production  (IEA)
positive regulation of interferon-gamma production  (ISO)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein K63-linked ubiquitination  (IBA)
positive regulation of toll-like receptor 3 signaling pathway  (IBA)
positive regulation of toll-like receptor 4 signaling pathway  (IBA)
positive regulation of toll-like receptor 7 signaling pathway  (IBA)
positive regulation of toll-like receptor 9 signaling pathway  (IBA)
positive regulation of type I interferon production  (ISO)
protein dephosphorylation  (ISO)
regulation of antigen processing and presentation  (ISO)
regulation of calcium ion transmembrane transport  (ISO)
regulation of leukocyte migration  (IEA)
regulation of natural killer cell proliferation  (ISO)
regulation of NIK/NF-kappaB signaling  (IBA)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
response to lipopolysaccharide  (ISO)
T cell differentiation  (IBA)
T cell receptor signaling pathway  (IBA)

Cellular Component

References

Genomics

Comparative Map Data
PTPN22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4106,686,604 - 106,758,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14106,692,102 - 106,758,101 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,897,216 - 116,927,483 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1113,813,811 - 113,871,753 (-)EnsemblGRCh38hg38GRCh38
GRCh381113,813,811 - 113,871,761 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371114,356,433 - 114,414,375 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,157,960 - 114,215,857 (-)NCBINCBI36hg18NCBI36
Build 341114,068,480 - 114,126,376NCBI
Celera1112,585,654 - 112,643,598 (-)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1112,214,556 - 112,272,493 (-)NCBIHuRef
CHM1_11114,471,278 - 114,529,231 (-)NCBICHM1_1
Ptpn22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393103,763,891 - 103,819,568 (+)NCBI
GRCm383103,856,575 - 103,912,252 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,859,795 - 103,912,247 (+)EnsemblGRCm38mm10GRCm38
MGSCv373103,664,215 - 103,716,170 (+)NCBIGRCm37mm9NCBIm37
MGSCv363103,989,353 - 104,041,308 (+)NCBImm8
Celera3106,063,559 - 106,114,657 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
Ptpn22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02206,342,066 - 206,390,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,342,066 - 206,390,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02225,765,744 - 225,814,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42199,083,186 - 199,144,309 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12199,045,987 - 199,095,515 (+)NCBI
Celera2183,836,919 - 183,884,957 (+)NCBICelera
Cytogenetic Map2q34NCBI
Ptpn22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543517,082,762 - 17,139,067 (-)NCBIChiLan1.0ChiLan1.0
PTPN22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11123,734,511 - 123,790,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1123,734,511 - 123,790,830 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0188,685,736 - 88,743,164 (+)NCBIMhudiblu_PPA_v0panPan3
PTPN22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1751,623,623 - 51,682,858 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11751,623,628 - 51,683,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ptpn22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366902,180,804 - 2,232,869 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN22
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2019,793,083 - 19,855,827 (+)Ensembl
ChlSab1.12019,792,807 - 19,855,784 (+)NCBI
Ptpn22
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247729,472,869 - 9,552,751 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 5 1
Low 8 1 2 2 2
Below cutoff 2 2 2 10 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007410   ⟹   ENSSSCP00000007215
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4106,687,787 - 106,758,099 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045740   ⟹   ENSSSCP00000042032
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4106,692,161 - 106,758,093 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000059891   ⟹   ENSSSCP00000054073
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4106,686,604 - 106,758,099 (+)Ensembl
RefSeq Acc Id: XM_021090718   ⟹   XP_020946377
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14106,692,102 - 106,758,101 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090719   ⟹   XP_020946378
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14106,692,102 - 106,758,101 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020946377 (Get FASTA)   NCBI Sequence Viewer  
  XP_020946378 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEA40660 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020946377   ⟸   XM_021090718
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020946378   ⟸   XM_021090719
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000054073   ⟸   ENSSSCT00000059891
RefSeq Acc Id: ENSSSCP00000042032   ⟸   ENSSSCT00000045740
RefSeq Acc Id: ENSSSCP00000007215   ⟸   ENSSSCT00000007410

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000007215 UniProtKB/TrEMBL
  ENSSSCP00000042032 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000054073 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007410 UniProtKB/TrEMBL
  ENSSSCT00000045740 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000059891 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene PTPN22 ENTREZGENE
Pfam Y_phosphatase UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A287ADW7_PIG UniProtKB/TrEMBL
  A0A287BD80_PIG UniProtKB/TrEMBL
  F1SBR0_PIG UniProtKB/TrEMBL
  H9LCC3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91978 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN22  protein tyrosine phosphatase non-receptor type 22    protein tyrosine phosphatase, non-receptor type 22  Symbol and/or name change 5135510 APPROVED