PFKM (phosphofructokinase, muscle) - Chinchilla Research Resource Database
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Gene: PFKM (phosphofructokinase, muscle) Sus scrofa
Analyze
Symbol: PFKM
Name: phosphofructokinase, muscle
CRRD ID: 14161991
Description: ENCODES a protein that exhibits 6-phosphofructokinase activity (ortholog); carbohydrate binding (ortholog); fructose binding (ortholog); INVOLVED IN glycolytic process (ortholog); muscle cell cellular homeostasis (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN Fanconi syndrome pathway; glycogen storage disease type VII pathway; glycolysis pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); glycogen storage disease (ortholog); glycogen storage disease VII (ortholog); FOUND IN apical plasma membrane (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; ATP-dependent 6-phosphofructokinase, muscle type; ATP-PFK; muscle 6-phosphofructokinase; muscle phosphofructokinase; PFK-A; PFK-M; PFMK; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase-M; phosphohexokinase
Orthologs:
Homo sapiens (human) : PFKM (phosphofructokinase, muscle)  HGNC  Alliance
Mus musculus (house mouse) : Pfkm (phosphofructokinase, muscle)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pfkm (phosphofructokinase, muscle)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pfkm (phosphofructokinase, muscle)
Pan paniscus (bonobo/pygmy chimpanzee) : PFKM (phosphofructokinase, muscle)
Canis lupus familiaris (dog) : PFKM (phosphofructokinase, muscle)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pfkm (phosphofructokinase, muscle)
Chlorocebus sabaeus (African green monkey) : PFKM (phosphofructokinase, muscle)
Heterocephalus glaber (naked mole-rat) : Pfkm (phosphofructokinase, muscle)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,475,540 - 78,526,995 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1578,475,473 - 78,525,052 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2581,673,123 - 81,695,166 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
PFKM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,475,540 - 78,526,995 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1578,475,473 - 78,525,052 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2581,673,123 - 81,695,166 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q25NCBI
PFKM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1248,105,139 - 48,146,404 (+)EnsemblGRCh38hg38GRCh38
GRCh381248,105,353 - 48,146,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371248,499,656 - 48,540,187 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,802,817 - 46,826,154 (+)NCBINCBI36hg18NCBI36
Build 341246,802,814 - 46,826,154NCBI
Celera1247,297,160 - 47,337,691 (+)NCBI
Cytogenetic Map12q13.11NCBI
HuRef1245,531,136 - 45,571,668 (+)NCBIHuRef
CHM1_11248,465,088 - 48,505,624 (+)NCBICHM1_1
Pfkm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391597,990,470 - 98,030,328 (+)NCBI
GRCm381598,092,589 - 98,132,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,092,589 - 98,132,451 (+)EnsemblGRCm38mm10GRCm38
MGSCv371597,923,020 - 97,962,878 (+)NCBIGRCm37mm9NCBIm37
MGSCv361597,940,155 - 97,960,485 (+)NCBImm8
Celera15100,219,444 - 100,262,084 (+)NCBICelera
Cytogenetic Map15F1NCBI
Pfkm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07139,702,066 - 139,722,132 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,685,573 - 139,722,132 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07138,837,772 - 138,857,276 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,826,122 - 136,846,040 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17136,898,639 - 136,922,477 (+)NCBI
Celera7125,730,934 - 125,751,002 (+)NCBICelera
Cytogenetic Map7q36NCBI
RH 3.4 Map71088.6RGD
Pfkm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555006,978,893 - 7,022,309 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555006,979,169 - 7,020,375 (+)NCBIChiLan1.0ChiLan1.0
PFKM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11241,459,346 - 41,500,101 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1241,459,346 - 41,499,476 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01240,584,321 - 40,625,245 (-)NCBIMhudiblu_PPA_v0panPan3
PFKM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl276,620,300 - 6,663,670 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1276,620,300 - 6,640,649 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pfkm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365126,006,247 - 6,031,939 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKM
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1144,334,605 - 44,377,877 (+)Ensembl
ChlSab1.11144,332,857 - 44,378,273 (+)NCBI
Pfkm
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248164,132,511 - 4,156,809 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 3 2 23
Low 8 2 5 2 3 2
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001044550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021091205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021091206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021091207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021091208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021091209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021091210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021091211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK349281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ363336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ480147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01073537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X94254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000029955   ⟹   ENSSSCP00000021675
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl578,476,350 - 78,525,050 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000043084   ⟹   ENSSSCP00000031975
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl578,475,540 - 78,525,052 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000043706   ⟹   ENSSSCP00000033725
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl578,499,200 - 78,525,052 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045119   ⟹   ENSSSCP00000053891
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl578,475,540 - 78,525,052 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048509   ⟹   ENSSSCP00000052677
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl578,500,458 - 78,526,995 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000049997   ⟹   ENSSSCP00000052093
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl578,475,540 - 78,525,052 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000058892   ⟹   ENSSSCP00000031307
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl578,476,287 - 78,525,050 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000066215   ⟹   ENSSSCP00000035163
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl578,475,540 - 78,525,052 (+)Ensembl
RefSeq Acc Id: NM_001044550   ⟹   NP_001038015
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1578,498,845 - 78,525,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091205   ⟹   XP_020946864
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1578,476,292 - 78,525,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091206   ⟹   XP_020946865
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1578,475,550 - 78,525,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091207   ⟹   XP_020946866
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1578,499,263 - 78,525,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091208   ⟹   XP_020946867
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1578,476,128 - 78,525,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091209   ⟹   XP_020946868
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1578,475,545 - 78,525,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091210   ⟹   XP_020946869
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1578,501,824 - 78,525,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091211   ⟹   XP_020946870
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1578,475,473 - 78,525,052 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020946870   ⟸   XM_021091211
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020946868   ⟸   XM_021091209
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020946865   ⟸   XM_021091206
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020946867   ⟸   XM_021091208
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020946864   ⟸   XM_021091205
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001038015   ⟸   NM_001044550
- UniProtKB: Q2HYU2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_020946866   ⟸   XM_021091207
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020946869   ⟸   XM_021091210
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000021675   ⟸   ENSSSCT00000029955
RefSeq Acc Id: ENSSSCP00000052677   ⟸   ENSSSCT00000048509
RefSeq Acc Id: ENSSSCP00000031307   ⟸   ENSSSCT00000058892
RefSeq Acc Id: ENSSSCP00000052093   ⟸   ENSSSCT00000049997
RefSeq Acc Id: ENSSSCP00000053891   ⟸   ENSSSCT00000045119
RefSeq Acc Id: ENSSSCP00000035163   ⟸   ENSSSCT00000066215
RefSeq Acc Id: ENSSSCP00000033725   ⟸   ENSSSCT00000043706
RefSeq Acc Id: ENSSSCP00000031975   ⟸   ENSSSCT00000043084
Protein Domains
PFK


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021129 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070008801 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000021675 UniProtKB/TrEMBL
  ENSSSCP00000031307 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000031975 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000033725 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000035163 UniProtKB/TrEMBL
  ENSSSCP00000052093 UniProtKB/TrEMBL
  ENSSSCP00000052677 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000053891 UniProtKB/TrEMBL
  ENSSSCP00070015612 UniProtKB/TrEMBL
  ENSSSCP00070015635 UniProtKB/TrEMBL
  ENSSSCP00070015672 UniProtKB/TrEMBL
  ENSSSCP00070015690 UniProtKB/TrEMBL
  ENSSSCP00070015696 UniProtKB/TrEMBL
  ENSSSCP00070015703 UniProtKB/TrEMBL
  ENSSSCP00070015711 UniProtKB/TrEMBL
  ENSSSCP00070015717 UniProtKB/TrEMBL
  ENSSSCP00070015733 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000029955 UniProtKB/TrEMBL
  ENSSSCT00000043084 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000043706 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000045119 UniProtKB/TrEMBL
  ENSSSCT00000048509 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000049997 UniProtKB/TrEMBL
  ENSSSCT00000058892 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000066215 UniProtKB/TrEMBL
  ENSSSCT00070018797 UniProtKB/TrEMBL
  ENSSSCT00070018823 UniProtKB/TrEMBL
  ENSSSCT00070018866 UniProtKB/TrEMBL
  ENSSSCT00070018884 UniProtKB/TrEMBL
  ENSSSCT00070018890 UniProtKB/TrEMBL
  ENSSSCT00070018898 UniProtKB/TrEMBL
  ENSSSCT00070018906 UniProtKB/TrEMBL
  ENSSSCT00070018919 UniProtKB/TrEMBL
  ENSSSCT00070018939 UniProtKB/TrEMBL
InterPro 6-Pfructokinase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_PFK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PFK_vert-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphofructokinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphofructokinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKF_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:733601 UniProtKB/Swiss-Prot
NCBI Gene PFKM ENTREZGENE
Pfam PFK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF ATP_PFK_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PHFRCTKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PHOSPHOFRUCTOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs 6PF1K_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.4741 ENTREZGENE
UniProt A0A286ZIJ9_PIG UniProtKB/TrEMBL
  A0A286ZKJ2_PIG UniProtKB/TrEMBL
  A0A286ZQ47_PIG UniProtKB/TrEMBL
  A0A286ZU66_PIG UniProtKB/TrEMBL
  A0A287B7N8_PIG UniProtKB/TrEMBL
  A0A287B8N1_PIG UniProtKB/TrEMBL
  A0A287BCP5_PIG UniProtKB/TrEMBL
  A0A4X1TGN2_PIG UniProtKB/TrEMBL
  A0A4X1TKH2_PIG UniProtKB/TrEMBL
  A0A4X1TKL1_PIG UniProtKB/TrEMBL
  A0A4X1TKN1_PIG UniProtKB/TrEMBL
  I3LCA1_PIG UniProtKB/TrEMBL
  PFKAM_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:91338 ENTREZGENE