IRF3 (interferon regulatory factor 3) - Chinchilla Research Resource Database
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Gene: IRF3 (interferon regulatory factor 3) Sus scrofa
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Symbol: IRF3
Name: interferon regulatory factor 3
CRRD ID: 14183272
Description: ENCODES a protein that exhibits identical protein binding (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cellular response to exogenous dsRNA (ortholog); cellular response to lipopolysaccharide (ortholog); defense response to virus (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH asthma (ortholog); bacterial pneumonia (ortholog); Herpes Simplex Encephalitis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IRF-3
Orthologs:
Homo sapiens (human) : IRF3 (interferon regulatory factor 3)  HGNC  Alliance
Mus musculus (house mouse) : Irf3 (interferon regulatory factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irf3 (interferon regulatory factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf3 (interferon regulatory factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF3 (interferon regulatory factor 3)
Canis lupus familiaris (dog) : IRF3 (interferon regulatory factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf3 (interferon regulatory factor 3)
Chlorocebus sabaeus (African green monkey) : IRF3 (interferon regulatory factor 3)
Heterocephalus glaber (naked mole-rat) : Irf3 (interferon regulatory factor 3)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,701,668 - 54,707,151 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,701,733 - 54,706,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,430,689 - 50,441,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleus  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17215286   PMID:17947522   PMID:19540847   PMID:20692306   PMID:21680532   PMID:25809915   PMID:27334592   PMID:31618847  


Genomics

Comparative Map Data
IRF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,701,668 - 54,707,151 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,701,733 - 54,706,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,430,689 - 50,441,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1949,659,569 - 49,665,875 (-)EnsemblGRCh38hg38GRCh38
GRCh381949,659,572 - 49,665,857 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,162,826 - 50,169,132 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,854,641 - 54,860,936 (-)NCBINCBI36hg18NCBI36
Build 341954,854,641 - 54,860,926NCBI
Celera1947,032,161 - 47,038,466 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1946,539,596 - 46,545,904 (-)NCBIHuRef
CHM1_11950,164,615 - 50,170,921 (-)NCBICHM1_1
Irf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,647,072 - 44,652,272 (+)NCBI
GRCm38744,997,648 - 45,002,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,997,648 - 45,002,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,253,030 - 52,258,218 (+)NCBIGRCm37mm9NCBIm37
MGSCv36744,865,702 - 44,870,890 (+)NCBImm8
Celera740,449,220 - 40,454,417 (+)NCBICelera
Cytogenetic Map7B3NCBI
Irf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01100,992,244 - 100,997,202 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,992,405 - 100,997,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,056,847 - 102,061,805 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,470,284 - 95,475,078 (+)NCBIRGSC3.4rn4RGSC3.4
Celera189,741,455 - 89,746,249 (+)NCBICelera
Cytogenetic Map1q22NCBI
Irf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,224,874 - 1,228,624 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,223,986 - 1,228,671 (+)NCBIChiLan1.0ChiLan1.0
IRF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11955,593,627 - 55,599,903 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,593,627 - 55,599,903 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01946,674,193 - 46,680,464 (-)NCBIMhudiblu_PPA_v0panPan3
IRF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1106,875,118 - 106,879,065 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11106,875,016 - 106,879,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Irf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366643,477,750 - 3,482,489 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl642,831,203 - 42,840,796 (-)Ensembl
ChlSab1.1642,835,285 - 42,841,487 (-)NCBI
Irf3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248324,611,445 - 4,616,319 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 3 5 4 2 3
Low 2 2 2 19 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003530   ⟹   ENSSSCP00000003447
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl654,701,668 - 54,706,502 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000033478   ⟹   ENSSSCP00000028920
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl654,701,668 - 54,707,151 (-)Ensembl
RefSeq Acc Id: NM_213770   ⟹   NP_998935
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,701,733 - 54,706,079 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_998935   ⟸   NM_213770
- UniProtKB: Q764M6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000003447   ⟸   ENSSSCT00000003530
RefSeq Acc Id: ENSSSCP00000028920   ⟸   ENSSSCT00000033478

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003178 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00040014662 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000003447 UniProtKB/TrEMBL
  ENSSSCP00000028920 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00040008173 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000003530 UniProtKB/TrEMBL
  ENSSSCT00000033478 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00040019663 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Interferon_reg_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_reg_fact_DNA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_reg_factor-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396656 UniProtKB/Swiss-Prot
NCBI Gene IRF3 ENTREZGENE
PANTHER PTHR11949 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTFRNREGFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IRF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.79511 ENTREZGENE
UniProt A9YTX9_PIG UniProtKB/TrEMBL
  F6PSB6_PIG UniProtKB/TrEMBL
  IRF3_PIG UniProtKB/Swiss-Prot
  K7GM32_PIG UniProtKB/TrEMBL
  Q764M6 ENTREZGENE
VGNC ID VGNC:89206 ENTREZGENE