CX3CR1 (C-X3-C motif chemokine receptor 1) - Chinchilla Research Resource Database
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Gene: CX3CR1 (C-X3-C motif chemokine receptor 1) Sus scrofa
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Symbol: CX3CR1
Name: C-X3-C motif chemokine receptor 1
CRRD ID: 14238081
Description: ENCODES a protein that exhibits chemokine receptor activity (ortholog); cytokine receptor activity (ortholog); G protein-coupled receptor activity (ortholog); INVOLVED IN autocrine signaling (ortholog); cell adhesion (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); ASSOCIATED WITH age related macular degeneration 12 (ortholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN cell surface (ortholog); dendritic tree (ortholog); neuron projection (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: CX3C chemokine receptor 1
Orthologs:
Homo sapiens (human) : CX3CR1 (C-X3-C motif chemokine receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Cx3cr1 (chemokine (C-X3-C motif) receptor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cx3cr1 (C-X3-C motif chemokine receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cx3cr1 (C-X3-C motif chemokine receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CX3CR1 (C-X3-C motif chemokine receptor 1)
Canis lupus familiaris (dog) : CX3CR1 (C-X3-C motif chemokine receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cx3cr1 (C-X3-C motif chemokine receptor 1)
Chlorocebus sabaeus (African green monkey) : CX3CR1 (C-X3-C motif chemokine receptor 1)
Heterocephalus glaber (naked mole-rat) : Cx3cr1 (C-X3-C motif chemokine receptor 1)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,944,369 - 23,957,486 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,944,386 - 23,957,567 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,204,842 - 26,218,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 12  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
arteriosclerosis  (ISO)
arthus reaction  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
borna disease  (ISO)
Chloracne  (ISO)
Chronic Mesangial Proliferative Glomerulonephritis  (ISO)
congestive heart failure  (ISO)
conjunctivitis  (ISO)
corneal neovascularization  (ISO)
Coronary Disease  (ISO)
cystitis  (ISO)
diabetes mellitus  (ISO)
Diabetes Mellitus, Experimental  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Graft vs Host Disease  (ISO)
Hearing Loss  (ISO)
hepatopulmonary syndrome  (ISO)
Herpes Simplex Encephalitis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
Inflammation  (ISO)
Intervertebral Disc Displacement  (ISO)
Intimal Hyperplasia  (ISO)
macular degeneration  (ISO)
Memory Disorders  (ISO)
Microscopic Polyangiitis  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
optic nerve glioma  (ISO)
otitis media  (ISO)
Pain  (ISO)
Parkinsonian Disorders  (ISO)
portal hypertension  (ISO)
prion disease  (ISO)
psoriasis  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
retinal degeneration  (ISO)
retinal vasculitis  (ISO)
retinitis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
status epilepticus  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autocrine signaling  (ISO)
calcium-mediated signaling  (IBA)
cell adhesion  (ISO)
cell chemotaxis  (IBA)
cellular response to lipopolysaccharide  (IEA)
cellular response to transforming growth factor beta stimulus  (ISO)
central nervous system maturation  (IEA)
cerebral cortex cell migration  (ISO)
chemokine-mediated signaling pathway  (IEA)
chemotaxis  (IBA)
cytokine-mediated signaling pathway  (ISO)
immune response  (IBA)
leukocyte tethering or rolling  (IEA)
macrophage chemotaxis  (ISO)
memory  (ISO)
microglial cell activation  (ISO)
microglial cell activation involved in immune response  (ISO)
modulation of chemical synaptic transmission  (IEA)
multiple spine synapse organization, single dendrite  (IEA)
negative regulation of angiogenesis  (IEA)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of chronic inflammatory response to non-antigenic stimulus  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of hippocampal neuron apoptotic process  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA)
positive regulation of angiogenesis  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of I-kappaB phosphorylation  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neurogenesis  (IEA)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
regulation of nitric oxide biosynthetic process  (IEA)
regulation of tumor necrosis factor production  (ISO)
response to ischemia  (ISO)
social behavior  (IEA)
synapse maturation  (IEA)

Cellular Component

References

Genomics

Comparative Map Data
CX3CR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,944,369 - 23,957,486 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,944,386 - 23,957,567 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,204,842 - 26,218,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CX3CR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl339,263,494 - 39,281,735 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl339,263,495 - 39,281,735 (-)EnsemblGRCh38hg38GRCh38
GRCh38339,263,494 - 39,281,735 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37339,304,985 - 39,323,226 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,279,989 - 39,296,531 (-)NCBINCBI36hg18NCBI36
Build 34339,279,990 - 39,296,526NCBI
Celera339,246,596 - 39,264,836 (-)NCBI
Cytogenetic Map3p22.2NCBI
HuRef339,347,466 - 39,365,706 (-)NCBIHuRef
CHM1_1339,256,125 - 39,274,344 (-)NCBICHM1_1
Cx3cr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,877,749 - 119,897,362 (-)NCBI
GRCm389120,048,683 - 120,068,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,901,616 - 120,069,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,957,811 - 119,977,400 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,897,391 - 119,916,980 (-)NCBImm8
Celera9120,518,248 - 120,537,939 (-)NCBICelera
Cytogenetic Map9F4NCBI
Cx3cr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,740,756 - 128,754,514 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,740,756 - 128,754,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,941,653 - 127,955,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,033,630 - 125,047,335 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18125,053,366 - 125,067,072 (-)NCBI
Celera8118,932,179 - 118,945,873 (-)NCBICelera
Cytogenetic Map8q32NCBI
Cx3cr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,701,073 - 24,707,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,691,206 - 24,705,599 (+)NCBIChiLan1.0ChiLan1.0
CX3CR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1339,439,009 - 39,456,797 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,440,955 - 39,457,219 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0339,158,346 - 39,176,604 (-)NCBI
CX3CR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl238,938,906 - 8,952,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1238,937,069 - 8,954,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cx3cr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647328,508,726 - 28,535,640 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CX3CR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl15150,718 - 151,785 (+)Ensembl
ChlSab1.115136,757 - 153,316 (+)NCBI
Cx3cr1
(Heterocephalus glaber - naked mole-rat)
No map positions available.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 16
Low 9 4 3 4 1 7 2 3 3
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000032483   ⟹   ENSSSCP00000021160
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1323,944,369 - 23,957,486 (-)Ensembl
RefSeq Acc Id: XM_003358374   ⟹   XP_003358422
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11323,944,386 - 23,957,567 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003358422 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003358422   ⟸   XM_003358374
- UniProtKB: I3LAU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000021160   ⟸   ENSSSCT00000032483
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024024 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070011495 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000021160 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070018507 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000032483 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070022354 UniProtKB/TrEMBL
InterPro Chemokine_CX3CR1 UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report ssc:100622126 UniProtKB/TrEMBL
NCBI Gene CX3CR1 ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS FRACTALKINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
UniGene Ssc.37404 ENTREZGENE
UniProt A0A4X1TT40_PIG UniProtKB/TrEMBL
  I3LAU2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87099 ENTREZGENE

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.