Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Smpd1 (sphingomyelin phosphodiesterase 1) Rattus norvegicus
Analyze
Symbol: Smpd1
Name: sphingomyelin phosphodiesterase 1
Description: Predicted to have acid sphingomyelin phosphodiesterase activity and zinc ion binding activity. Involved in ceramide biosynthetic process; positive regulation of apoptotic process; and response to cocaine. Localizes to the extracellular space and lamellar body. Used to study Wilson disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease; Niemann-Pick disease type A; and Niemann-Pick disease type B. Orthologous to human SMPD1 (sphingomyelin phosphodiesterase 1); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; bezafibrate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC94748; sphingomyelin phosphodiesterase; sphingomyelin phosphodiesterase 1, acid lysosomal
Orthologs:
Homo sapiens (human) : SMPD1 (sphingomyelin phosphodiesterase 1)  HGNC  Alliance
Mus musculus (house mouse) : Smpd1 (sphingomyelin phosphodiesterase 1, acid lysosomal)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smpd1 (sphingomyelin phosphodiesterase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SMPD1 (sphingomyelin phosphodiesterase 1)
Canis lupus familiaris (dog) : SMPD1 (sphingomyelin phosphodiesterase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smpd1 (sphingomyelin phosphodiesterase 1)
Sus scrofa (pig) : SMPD1 (sphingomyelin phosphodiesterase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01170,383,682 - 170,387,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01177,389,588 - 177,393,431 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,278,970 - 163,282,813 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1157,825,620 - 157,829,463 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Smpd1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1549719
Created: 2005-09-15
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.