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Gene: Lars (leucyl-tRNA synthetase) Mus musculus
Symbol: Lars
Name: leucyl-tRNA synthetase
Description: Exhibits leucine-tRNA ligase activity. Involved in leucyl-tRNA aminoacylation. Localizes to aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human LARS1 (leucyl-tRNA synthetase 1); PARTICIPATES IN valine, leucine and isoleucine biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310045K21Rik; 3110009L02Rik; AW536573; Lars1; leucine--tRNA ligase; leucine--tRNA ligase, cytoplasmic; leucyl-tRNA synthetase, cytoplasmic; leuRS; mKIAA1352
Homo sapiens (human) : LARS1 (leucyl-tRNA synthetase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lars1 (leucyl-tRNA synthetase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lars1 (leucyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LARS1 (leucyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : LARS1 (leucyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lars1 (leucyl-tRNA synthetase 1)
Sus scrofa (pig) : LARS1 (leucyl-tRNA synthetase 1)
Chlorocebus sabaeus (African green monkey) : LARS1 (leucyl-tRNA synthetase 1)
Heterocephalus glaber (naked mole-rat) : Lars1 (leucyl-tRNA synthetase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1842,202,298 - 42,262,194 (-)EnsemblGRCm38mm10GRCm38
GRCm381842,202,298 - 42,262,237 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371842,362,003 - 42,421,725 (-)NCBIGRCm37mm9NCBIm37
MGSCv361842,328,271 - 42,388,167 (-)NCBImm8
Celera1843,563,719 - 43,623,468 (-)NCBICelera
Cytogenetic Map18B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lars
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550076
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.