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Gene: Kras (Kirsten rat sarcoma viral oncogene homolog) Mus musculus
Symbol: Kras
Name: Kirsten rat sarcoma viral oncogene homolog
Description: Exhibits GTPase activity. Involved in several processes, including endocrine signaling; forebrain astrocyte development; and modulation of chemical synaptic transmission. Localizes to the membrane. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; autoimmune lymphoproliferative syndrome type 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Orthologous to human KRAS (KRAS proto-oncogene, GTPase); PARTICIPATES IN altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; endometrial cancer pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (trichloromethyl)benzene; 1,1-dichloroethene; 1-nitropyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI929937; c-K-ras; c-Ki-ras; GTPase KRas; K-ras; K-Ras 2; Ki-ras; Kirsten rat sarcoma oncogene 2, expressed; Kras-2; Kras2; MGC7141; p21 protein; p21B; ras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Homo sapiens (human) : KRAS (KRAS proto-oncogene, GTPase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kras (KRAS proto-oncogene, GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kras (KRAS proto-oncogene, GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : KRAS (KRAS proto-oncogene, GTPase)
Canis lupus familiaris (dog) : KRAS (KRAS proto-oncogene, GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kras (KRAS proto-oncogene, GTPase)
Sus scrofa (pig) : KRAS (KRAS proto-oncogene, GTPase)
Chlorocebus sabaeus (African green monkey) : KRAS (KRAS proto-oncogene, GTPase)
Heterocephalus glaber (naked mole-rat) : Kras (KRAS proto-oncogene, GTPase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl6145,216,699 - 145,250,239 (-)Ensembl
GRCm386145,216,699 - 145,250,420 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376145,165,219 - 145,198,751 (-)NCBIGRCm37mm9NCBIm37
MGSCv366145,173,866 - 145,207,390 (-)NCBImm8
Celera6148,290,985 - 148,324,546 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Kras
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550157
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.