Ankle1 (ankyrin repeat and LEM domain containing 1) - Chinchilla Research Resource Database
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Gene: Ankle1 (ankyrin repeat and LEM domain containing 1) Mus musculus
Analyze
Symbol: Ankle1
Name: ankyrin repeat and LEM domain containing 1
CRRD ID: 1550241
Description: Predicted to have endonuclease activity. Involved in negative regulation of mitotic recombination; regulation of lymphoid progenitor cell differentiation; and regulation of myeloid progenitor cell differentiation. Predicted to colocalize with nucleus. Orthologous to human ANKLE1 (ankyrin repeat and LEM domain containing 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 8430438L13Rik; Ankr; Ankrd41; ankyrin repeat and LEM domain-containing protein 1; ankyrin repeat domain 41; ankyrin repeat domain-containing protein 41; C430003I23; LEM-domain containing 3; LEM-domain containing protein 3; Lem3
Orthologs:
Homo sapiens (human) : ANKLE1 (ankyrin repeat and LEM domain containing 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ankle1 (ankyrin repeat and LEM domain containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ankle1 (ankyrin repeat and LEM domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ANKLE1 (ankyrin repeat and LEM domain containing 1)
Canis lupus familiaris (dog) : ANKLE1 (ankyrin repeat and LEM domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ankle1 (ankyrin repeat and LEM domain containing 1)
Sus scrofa (pig) : ANKLE1 (ankyrin repeat and LEM domain containing 1)
Chlorocebus sabaeus (African green monkey) : ANKLE1 (ankyrin repeat and LEM domain containing 1)
Heterocephalus glaber (naked mole-rat) : Ankle1 (ankyrin repeat and LEM domain containing 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,858,630 - 71,868,475 (+)NCBI
GRCm38871,405,986 - 71,410,728 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,406,010 - 71,409,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,929,911 - 73,933,803 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,335,005 - 74,338,857 (+)NCBImm8
Celera873,930,693 - 73,934,585 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:27010503  


Genomics

Comparative Map Data
Ankle1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,858,630 - 71,868,475 (+)NCBI
GRCm38871,405,986 - 71,410,728 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,406,010 - 71,409,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,929,911 - 73,933,803 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,335,005 - 74,338,857 (+)NCBImm8
Celera873,930,693 - 73,934,585 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
ANKLE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,281,645 - 17,287,646 (+)EnsemblGRCh38hg38GRCh38
GRCh381917,281,901 - 17,287,646 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,392,454 - 17,398,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,253,454 - 17,259,454 (+)NCBINCBI36hg18NCBI36
Celera1917,294,193 - 17,300,193 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1916,959,113 - 16,965,109 (+)NCBIHuRef
CHM1_11917,391,919 - 17,397,928 (+)NCBICHM1_1
Ankle1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,799,943 - 19,826,057 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,800,463 - 19,803,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,660,504 - 19,666,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,565,676 - 18,569,219 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,565,673 - 18,569,007 (+)NCBI
Celera1618,281,567 - 18,307,663 (+)NCBICelera
Cytogenetic Map16p14NCBI
Ankle1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955524933,200 - 936,933 (-)NCBIChiLan1.0ChiLan1.0
ANKLE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,744,570 - 17,750,070 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,744,570 - 17,750,070 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01916,769,670 - 16,775,114 (+)NCBIMhudiblu_PPA_v0panPan3
ANKLE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,461,676 - 45,465,417 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,461,135 - 45,465,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ankle1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,568,810 - 3,573,506 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKLE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,391,111 - 60,396,462 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,391,110 - 60,397,559 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ANKLE1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl615,789,355 - 15,795,025 (+)Ensembl
ChlSab1.1615,788,861 - 15,794,825 (+)NCBI
Ankle1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908649,371 - 654,588 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:610
Count of miRNA genes:383
Interacting mature miRNAs:438
Transcripts:ENSMUST00000119976, ENSMUST00000120725, ENSMUST00000124520, ENSMUST00000125290, ENSMUST00000136522
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001310502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ046325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU184014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000119976   ⟹   ENSMUSP00000113162
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,406,010 - 71,409,904 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120725   ⟹   ENSMUSP00000112797
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,406,024 - 71,409,483 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124520
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,406,022 - 71,409,476 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125290
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,406,016 - 71,409,868 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136522
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,407,691 - 71,409,157 (+)Ensembl
RefSeq Acc Id: NM_001310502   ⟹   NP_001297431
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,858,656 - 71,863,186 (+)NCBI
GRCm38871,406,012 - 71,410,542 (+)NCBI
Sequence:
RefSeq Acc Id: NM_172756   ⟹   NP_766344
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,858,656 - 71,863,186 (+)NCBI
GRCm38871,406,012 - 71,410,542 (+)NCBI
MGSCv37873,929,911 - 73,933,803 (+)RGD
Celera873,930,693 - 73,934,585 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509661   ⟹   XP_006509724
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,858,630 - 71,868,475 (+)NCBI
GRCm38871,405,986 - 71,410,728 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030243488   ⟹   XP_030099348
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,858,653 - 71,863,372 (+)NCBI
GRCm38871,406,884 - 71,410,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153950   ⟹   XP_036009843
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,858,830 - 71,868,475 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_766344   ⟸   NM_172756
- Peptide Label: isoform 1
- UniProtKB: A8VU90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509724   ⟸   XM_006509661
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001297431   ⟸   NM_001310502
- Peptide Label: isoform 2
- UniProtKB: A8VU90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030099348   ⟸   XM_030243488
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000113162   ⟸   ENSMUST00000119976
RefSeq Acc Id: ENSMUSP00000112797   ⟸   ENSMUST00000120725
RefSeq Acc Id: XP_036009843   ⟸   XM_036153950
- Peptide Label: isoform X2
Protein Domains
GIY-YIG   LEM

Promoters
RGD ID:8667391
Promoter ID:EPDNEW_M11727
Type:initiation region
Name:Ankle1_1
Description:Mus musculus ankyrin repeat and LEM domain containing 1 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,406,022 - 71,406,082EPDNEW
RGD ID:6842781
Promoter ID:MM_KWN:54780
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000119976,   OTTMUST00000073968,   OTTMUST00000073969,   UC009MDC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,929,561 - 73,930,061 (+)MPROMDB
RGD ID:6842767
Promoter ID:MM_KWN:54781
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000073970
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,930,586 - 73,931,086 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918775 AgrOrtholog
Ensembl Genes ENSMUSG00000046295 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000112797 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000113162 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000119976 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000120725 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.720.40 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
InterPro ANKLE1 UniProtKB/Swiss-Prot
  Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_dom UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  GIY-YIG_SF UniProtKB/Swiss-Prot
  LEM/LEM-like_dom UniProtKB/Swiss-Prot
  LEM_dom UniProtKB/Swiss-Prot
KEGG Report mmu:234396 UniProtKB/Swiss-Prot
MGD MGI:1918775 ENTREZGENE
NCBI Gene 234396 ENTREZGENE
PANTHER PTHR46427 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  LEM UniProtKB/Swiss-Prot
PhenoGen Ankle1 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  GIY_YIG UniProtKB/Swiss-Prot
  LEM UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
  SSF63451 UniProtKB/Swiss-Prot
UniGene Mm.216549 ENTREZGENE
UniProt A8VU90 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A6H5W1 UniProtKB/Swiss-Prot
  G5E8T1 UniProtKB/Swiss-Prot
  Q8C4V5 UniProtKB/Swiss-Prot
  Q8K2N6 UniProtKB/Swiss-Prot