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Gene: Smad5 (SMAD family member 5) Mus musculus
Symbol: Smad5
Name: SMAD family member 5
CRRD ID: 1550273
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; egg cylinder; embryo mesenchyme; and genitourinary system. Orthologous to human SMAD5 (SMAD family member 5); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110051M15Rik; AI451355; dwarfin-C; Dwf-C; MAD homolog 5; Madh; Madh5; mothers against decapentaplegic homolog 5; mothers against DPP homolog 5; mSmad5; Mus; MusMLP; Smad 5
Homo sapiens (human) : SMAD5 (SMAD family member 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Smad5 (SMAD family member 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad5 (SMAD family member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD5 (SMAD family member 5)
Canis lupus familiaris (dog) : SMAD5 (SMAD family member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad5 (SMAD family member 5)
Sus scrofa (pig) : SMAD5 (SMAD family member 5)
Chlorocebus sabaeus (African green monkey) : SMAD5 (SMAD family member 5)
Heterocephalus glaber (naked mole-rat) : Smad5 (SMAD family member 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391356,850,804 - 56,890,191 (+)NCBI
GRCm381356,703,010 - 56,742,378 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,703,010 - 56,742,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371356,804,371 - 56,843,739 (+)NCBIGRCm37mm9NCBIm37
MGSCv361356,733,051 - 56,751,999 (+)NCBImm8
Celera1357,765,382 - 57,797,308 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Smad5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550273
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-11-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.