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Gene: Kars (lysyl-tRNA synthetase) Mus musculus
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Symbol: Kars
Name: lysyl-tRNA synthetase
Description: Exhibits scaffold protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; diadenosine tetraphosphate biosynthetic process; and positive regulation of macromolecule metabolic process. Localizes to aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA589550; AL024334; AL033315; AL033367; D8Ertd698e; D8Wsu108e; Kars1; lysine--tRNA ligase; LysRS; mKIAA0070
Orthologs:
Homo sapiens (human) : KARS1 (lysyl-tRNA synthetase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kars (lysyl-tRNA synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kars1 (lysyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KARS1 (lysyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : KARS1 (lysyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kars1 (lysyl-tRNA synthetase 1)
Sus scrofa (pig) : KARS1 (lysyl-tRNA synthetase 1)
Chlorocebus sabaeus (African green monkey) : KARS1 (lysyl-tRNA synthetase 1)
Heterocephalus glaber (naked mole-rat) : Kars1 (lysyl-tRNA synthetase 1)
more info ...
Related Pseudogenes: Gm15081   Gm15096   Gm18066   Gm7155   Gm8303   Gm8320   Gm8331   Gm8346   Gm8366   Gm8383   Gm8402   Gm8428   Kars-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl8111,993,443 - 112,011,323 (-)EnsemblGRCm38mm10GRCm38
GRCm388111,993,439 - 112,011,354 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378114,517,340 - 114,535,205 (-)NCBIGRCm37mm9NCBIm37
MGSCv368114,880,116 - 114,897,941 (-)NCBImm8
Celera8116,222,771 - 116,240,662 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map858.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Kars
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550396
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.