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Gene: Kars (lysyl-tRNA synthetase) Mus musculus
Symbol: Kars
Name: lysyl-tRNA synthetase
Description: Exhibits scaffold protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; diadenosine tetraphosphate biosynthetic process; and positive regulation of macromolecule metabolic process. Localizes to aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA589550; AL024334; AL033315; AL033367; D8Ertd698e; D8Wsu108e; Kars1; lysine--tRNA ligase; LysRS; mKIAA0070
Homo sapiens (human) : KARS1 (lysyl-tRNA synthetase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kars (lysyl-tRNA synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kars1 (lysyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KARS1 (lysyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : KARS1 (lysyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kars1 (lysyl-tRNA synthetase 1)
Sus scrofa (pig) : KARS1 (lysyl-tRNA synthetase 1)
Chlorocebus sabaeus (African green monkey) : KARS1 (lysyl-tRNA synthetase 1)
Heterocephalus glaber (naked mole-rat) : Kars1 (lysyl-tRNA synthetase 1)
more info ...
Related Pseudogenes: Gm15081   Gm15096   Gm18066   Gm7155   Gm8303   Gm8320   Gm8331   Gm8346   Gm8366   Gm8383   Gm8402   Gm8428   Kars-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl8111,993,443 - 112,011,323 (-)EnsemblGRCm38mm10GRCm38
GRCm388111,993,439 - 112,011,354 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378114,517,340 - 114,535,205 (-)NCBIGRCm37mm9NCBIm37
MGSCv368114,880,116 - 114,897,941 (-)NCBImm8
Celera8116,222,771 - 116,240,662 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map858.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Kars
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550396
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.