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Gene: Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2) Mus musculus
Symbol: Ace2
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Description: Predicted to have endopeptidase activity; metallocarboxypeptidase activity; and virus receptor activity. Involved in positive regulation of cardiac muscle contraction and tryptophan transport. Localizes to brush border membrane and cytoplasm. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; avian influenza; diabetic retinopathy; respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin I converting enzyme 2); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH 14,15-EET; Benzo[k]fluoranthene; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2010305L05Rik; ACE-related carboxypeptidase; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2
Homo sapiens (human) : ACE2 (angiotensin I converting enzyme 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ace2 (angiotensin I converting enzyme 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ace2 (angiotensin I converting enzyme 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACE2 (angiotensin I converting enzyme 2)
Canis lupus familiaris (dog) : ACE2 (angiotensin I converting enzyme 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ace2 (angiotensin I converting enzyme 2)
Sus scrofa (pig) : ACE2 (angiotensin I converting enzyme 2)
Chlorocebus sabaeus (African green monkey) : ACE2 (angiotensin I converting enzyme 2)
Heterocephalus glaber (naked mole-rat) : Ace2 (angiotensin I converting enzyme 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBImm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Protein Structures

Additional Information

External Database Links
More on Ace2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550521
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.