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Gene: H2-T3 (histocompatibility 2, T region locus 3) Mus musculus
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Symbol: H2-T3
Name: histocompatibility 2, T region locus 3
CRRD ID: 1550670
Description: Predicted to have peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to localize to external side of plasma membrane and extracellular space. Is expressed in small intestine and thymus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); eye disease (multiple); human immunodeficiency virus infectious disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chromium(6+).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: H-2 class I histocompatibility antigen, TLA(B) alpha chain; H-2T3; H2-Tw3; MHC c5/g1L protein; MHC class I antigen; MHC thymus leukemia antigen; MHC-TLA-T13a; MumuTL; T; thymus leukemia antigen; TL; TL antigen
Orthologs:
No known orthologs. homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,496,463 - 36,501,043 (-)NCBI
GRCm381736,185,571 - 36,190,151 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1736,185,572 - 36,190,287 (-)EnsemblGRCm38mm10GRCm38
MGSCv371736,322,516 - 36,327,096 (-)NCBIGRCm37mm9NCBIm37
MGSCv361735,793,624 - 35,798,204 (-)NCBImm8
Celera1739,659,082 - 39,663,660 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on H2-T3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550670
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.