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Gene: H2-T3 (histocompatibility 2, T region locus 3) Mus musculus
Symbol: H2-T3
Name: histocompatibility 2, T region locus 3
CRRD ID: 1550670
Description: Predicted to have peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to localize to external side of plasma membrane and extracellular space. Is expressed in small intestine and thymus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); eye disease (multiple); human immunodeficiency virus infectious disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chromium(6+).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: H-2 class I histocompatibility antigen, TLA(B) alpha chain; H-2T3; H2-Tw3; MHC c5/g1L protein; MHC class I antigen; MHC thymus leukemia antigen; MHC-TLA-T13a; MumuTL; T; thymus leukemia antigen; TL; TL antigen
No known orthologs. homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391736,496,463 - 36,501,043 (-)NCBI
GRCm381736,185,571 - 36,190,151 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1736,185,572 - 36,190,287 (-)EnsemblGRCm38mm10GRCm38
MGSCv371736,322,516 - 36,327,096 (-)NCBIGRCm37mm9NCBIm37
MGSCv361735,793,624 - 35,798,204 (-)NCBImm8
Celera1739,659,082 - 39,663,660 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on H2-T3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550670
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.