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Gene: Hnf4a (hepatic nuclear factor 4, alpha) Mus musculus
Symbol: Hnf4a
Name: hepatic nuclear factor 4, alpha
CRRD ID: 1550718
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including SMAD protein signal transduction; lipid homeostasis; and regulation of gene expression. Localizes to nucleus. Is expressed in several structures, including ear; early conceptus; gut; metanephros; and nervous system. Used to study Fanconi syndrome and maturity-onset diabetes of the young type 1. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hepatocyte nuclear factor 4-alpha; Hnf; HNF-; HNF-4; HNF-4-alpha; Hnf4; HNF4 alpha; Hnf4alpha; HNF4alpha10; HNF4alpha11; HNF4alpha12; MODY; MODY1; Nr; Nr2a1; Nuclear receptor 2A1; nuclear receptor subfamily 2 group A member 1; TCF-14; Tcf14; Tcf4; transcription factor 14; transcription factor HNF-4
Homo sapiens (human) : HNF4A (hepatocyte nuclear factor 4 alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hnf4a (hepatocyte nuclear factor 4, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF4A (hepatocyte nuclear factor 4 alpha)
Canis lupus familiaris (dog) : HNF4A (hepatocyte nuclear factor 4 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Sus scrofa (pig) : HNF4A (hepatocyte nuclear factor 4 alpha)
Chlorocebus sabaeus (African green monkey) : HNF4A (hepatocyte nuclear factor 4 alpha)
Heterocephalus glaber (naked mole-rat) : Hnf4a (hepatocyte nuclear factor 4 alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392163,348,731 - 163,414,827 (+)NCBI
GRCm382163,506,811 - 163,572,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,506,808 - 163,572,910 (+)EnsemblGRCm38mm10GRCm38
MGSCv372163,372,924 - 163,398,643 (+)NCBIGRCm37mm9NCBIm37
MGSCv362163,238,629 - 163,264,348 (+)NCBImm8
Celera2169,490,574 - 169,516,277 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hnf4a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550718
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.