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Gene: Hnf4a (hepatic nuclear factor 4, alpha) Mus musculus
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Symbol: Hnf4a
Name: hepatic nuclear factor 4, alpha
CRRD ID: 1550718
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including SMAD protein signal transduction; lipid homeostasis; and regulation of gene expression. Localizes to nucleus. Is expressed in several structures, including ear; early conceptus; gut; metanephros; and nervous system. Used to study Fanconi syndrome and maturity-onset diabetes of the young type 1. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hepatocyte nuclear factor 4-alpha; Hnf; HNF-; HNF-4; HNF-4-alpha; Hnf4; HNF4 alpha; Hnf4alpha; HNF4alpha10; HNF4alpha11; HNF4alpha12; MODY; MODY1; Nr; Nr2a1; Nuclear receptor 2A1; nuclear receptor subfamily 2 group A member 1; TCF-14; Tcf14; Tcf4; transcription factor 14; transcription factor HNF-4
Orthologs:
Homo sapiens (human) : HNF4A (hepatocyte nuclear factor 4 alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hnf4a (hepatocyte nuclear factor 4, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF4A (hepatocyte nuclear factor 4 alpha)
Canis lupus familiaris (dog) : HNF4A (hepatocyte nuclear factor 4 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Sus scrofa (pig) : HNF4A (hepatocyte nuclear factor 4 alpha)
Chlorocebus sabaeus (African green monkey) : HNF4A (hepatocyte nuclear factor 4 alpha)
Heterocephalus glaber (naked mole-rat) : Hnf4a (hepatocyte nuclear factor 4 alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,348,731 - 163,414,827 (+)NCBI
GRCm382163,506,811 - 163,572,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,506,808 - 163,572,910 (+)EnsemblGRCm38mm10GRCm38
MGSCv372163,372,924 - 163,398,643 (+)NCBIGRCm37mm9NCBIm37
MGSCv362163,238,629 - 163,264,348 (+)NCBImm8
Celera2169,490,574 - 169,516,277 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hnf4a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550718
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.