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Gene: Plekhg5 (pleckstrin homology domain containing, family G (with RhoGef domain) member 5) Mus musculus
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Symbol: Plekhg5
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Description: Exhibits Rho guanyl-nucleotide exchange factor activity. Involved in endothelial cell chemotaxis and regulation of protein catabolic process at presynapse, modulating synaptic transmission. Localizes to several cellular components, including cell-cell junction; endocytic vesicle; and lamellipodium. Is expressed in brain and cardiovascular system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and distal spinal muscular atrophy type 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BC023181; Gm8400; mKIAA0720; PH domain-containing family G member 5; pleckstrin homology domain-containing family G member 5; predicted gene 8400; RhoA-specific guanine exchange factor SYX1; RhoA-specific guanine exchange factor SYX2; RP23-284C20.1; synectin-binding RhoA exchange factor; Syx
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl4152,072,498 - 152,115,400 (+)EnsemblGRCm38mm10GRCm38
GRCm384152,072,433 - 152,115,404 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374151,470,828 - 151,489,509 (+)NCBIGRCm37mm9NCBIm37
MGSCv364150,940,519 - 150,959,200 (+)NCBImm8
Celera4154,383,207 - 154,401,930 (+)NCBICelera
Cytogenetic Map4E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Plekhg5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550862
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.