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Gene: Plekhg5 (pleckstrin homology domain containing, family G (with RhoGef domain) member 5) Mus musculus
Symbol: Plekhg5
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Description: Exhibits Rho guanyl-nucleotide exchange factor activity. Involved in endothelial cell chemotaxis and regulation of protein catabolic process at presynapse, modulating synaptic transmission. Localizes to several cellular components, including cell-cell junction; endocytic vesicle; and lamellipodium. Is expressed in brain and cardiovascular system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and distal spinal muscular atrophy type 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BC023181; Gm8400; mKIAA0720; PH domain-containing family G member 5; pleckstrin homology domain-containing family G member 5; predicted gene 8400; RhoA-specific guanine exchange factor SYX1; RhoA-specific guanine exchange factor SYX2; RP23-284C20.1; synectin-binding RhoA exchange factor; Syx
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl4152,072,498 - 152,115,400 (+)EnsemblGRCm38mm10GRCm38
GRCm384152,072,433 - 152,115,404 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374151,470,828 - 151,489,509 (+)NCBIGRCm37mm9NCBIm37
MGSCv364150,940,519 - 150,959,200 (+)NCBImm8
Celera4154,383,207 - 154,401,930 (+)NCBICelera
Cytogenetic Map4E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Plekhg5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550862
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.