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Gene: H2-Ke6 (H2-K region expressed gene 6) Mus musculus
Symbol: H2-Ke6
Name: H2-K region expressed gene 6
CRRD ID: 1550967
Description: Exhibits estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Involved in androgen metabolic process and estrogen metabolic process. Localizes to mitochondrial envelope and plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8); PARTICIPATES IN steroid hormone biosynthetic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; D17H6S112E; estradiol 17-beta-dehydrogenase 8; estrogen 17-oxidoreductase; H-2Ke6; Hsd17b8; KAR alpha subunit; Ke-6; Ke6; MGC107650; Ri; Ring2; testosterone 17-beta-dehydrogenase 8
Homo sapiens (human) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hsd17b8 (hydroxysteroid (17-beta) dehydrogenase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Canis lupus familiaris (dog) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8)
Sus scrofa (pig) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Chlorocebus sabaeus (African green monkey) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Heterocephalus glaber (naked mole-rat) : Hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391734,245,007 - 34,247,029 (-)NCBI
GRCm381734,026,033 - 34,028,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,026,033 - 34,028,060 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,162,978 - 34,165,000 (-)NCBIGRCm37mm9NCBIm37
MGSCv361733,636,489 - 33,638,511 (-)NCBImm8
Celera1736,772,162 - 36,774,185 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on H2-Ke6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1550967
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.