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Gene: Tlr2 (toll-like receptor 2) Mus musculus
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Symbol: Tlr2
Name: toll-like receptor 2
Description: Exhibits lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including positive regulation of defense response; regulation of cytokine production; and response to bacterium. Localizes to Toll-like receptor 2-Toll-like receptor 6 protein complex and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in several diseases, including dermatitis (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2); PARTICIPATES IN Toll-like receptor signaling pathway; Chagas disease pathway; Entamoebiasis pathway; INTERACTS WITH (+)-pilocarpine; (-)-citrinin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ly105
Orthologs:
Homo sapiens (human) : TLR2 (toll like receptor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tlr2 (toll-like receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr2 (toll like receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR2 (toll like receptor 2)
Canis lupus familiaris (dog) : TLR2 (toll like receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr2 (toll like receptor 2)
Sus scrofa (pig) : TLR2 (toll like receptor 2)
Heterocephalus glaber (naked mole-rat) : Tlr2 (toll like receptor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl383,836,272 - 83,841,767 (-)EnsemblGRCm38mm10GRCm38
GRCm38383,836,272 - 83,841,824 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37383,640,194 - 83,645,530 (-)NCBIGRCm37mm9NCBIm37
MGSCv36383,922,199 - 83,927,694 (-)NCBImm8
Celera383,852,064 - 83,857,400 (-)NCBICelera
Cytogenetic Map3E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tlr2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1551003
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.