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Gene: Ncstn (nicastrin) Mus musculus
Symbol: Ncstn
Name: nicastrin
Description: Contributes to endopeptidase activity. Involved in several processes, including amyloid precursor protein biosynthetic process; positive regulation of amyloid precursor protein biosynthetic process; and regulation of synaptic plasticity. Localizes to several cellular components, including Golgi apparatus; lysosome; and synaptic vesicle. Used to study chronic myeloid leukemia; schizophrenia; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Is expressed in several structures, including brain and genitourinary system. Orthologous to human NCSTN (nicastrin); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; dioxygen.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9430068N19Rik; AA727311; Aph2; D1Dau13e; Kiaa0253; mKIAA0253; Nct
Homo sapiens (human) : NCSTN (nicastrin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ncstn (nicastrin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncstn (nicastrin)
Pan paniscus (bonobo/pygmy chimpanzee) : NCSTN (nicastrin)
Canis lupus familiaris (dog) : NCSTN (nicastrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncstn (nicastrin)
Sus scrofa (pig) : NCSTN (nicastrin)
Chlorocebus sabaeus (African green monkey) : NCSTN (nicastrin)
Heterocephalus glaber (naked mole-rat) : Ncstn (nicastrin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1172,066,013 - 172,082,795 (-)EnsemblGRCm38mm10GRCm38
GRCm381172,066,013 - 172,082,789 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371173,996,144 - 174,012,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv361173,902,773 - 173,919,369 (-)NCBImm8
Celera1174,920,243 - 174,937,040 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ncstn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1551174
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.