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Gene: Ncstn (nicastrin) Mus musculus
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Symbol: Ncstn
Name: nicastrin
Description: Contributes to endopeptidase activity. Involved in several processes, including amyloid precursor protein biosynthetic process; positive regulation of amyloid precursor protein biosynthetic process; and regulation of synaptic plasticity. Localizes to several cellular components, including Golgi apparatus; lysosome; and synaptic vesicle. Used to study chronic myeloid leukemia; schizophrenia; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Is expressed in several structures, including brain and genitourinary system. Orthologous to human NCSTN (nicastrin); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; dioxygen.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9430068N19Rik; AA727311; Aph2; D1Dau13e; Kiaa0253; mKIAA0253; Nct
Orthologs:
Homo sapiens (human) : NCSTN (nicastrin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ncstn (nicastrin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncstn (nicastrin)
Pan paniscus (bonobo/pygmy chimpanzee) : NCSTN (nicastrin)
Canis lupus familiaris (dog) : NCSTN (nicastrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncstn (nicastrin)
Sus scrofa (pig) : NCSTN (nicastrin)
Chlorocebus sabaeus (African green monkey) : NCSTN (nicastrin)
Heterocephalus glaber (naked mole-rat) : Ncstn (nicastrin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1172,066,013 - 172,082,795 (-)EnsemblGRCm38mm10GRCm38
GRCm381172,066,013 - 172,082,789 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371173,996,144 - 174,012,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv361173,902,773 - 173,919,369 (-)NCBImm8
Celera1174,920,243 - 174,937,040 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ncstn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1551174
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.