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Gene: Erbb4 (erb-b2 receptor tyrosine kinase 4) Mus musculus
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Symbol: Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Description: Exhibits protein tyrosine kinase activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of signal transduction. Localizes to the GABA-ergic synapse; glutamatergic synapse; and integral component of synaptic membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19 and colorectal cancer. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; heart; and mammary gland primordium. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: avian erythroblastosis oncogene B 4; c-erbB-4; Her4; proto-oncogene-like protein c-ErbB-4; receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4
Orthologs:
Homo sapiens (human) : ERBB4 (erb-b2 receptor tyrosine kinase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Erbb4 (erb-b2 receptor tyrosine kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erbb4 (erb-b2 receptor tyrosine kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
Canis lupus familiaris (dog) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Erbb4 (erb-b2 receptor tyrosine kinase 4)
Sus scrofa (pig) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38168,031,884 - 69,108,576 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37168,086,540 - 69,154,633 (-)NCBIGRCm37mm9NCBIm37
MGSCv36167,973,174 - 69,041,267 (-)NCBImm8
Celera168,604,658 - 69,678,621 (-)NCBICelera
Cytogenetic Map1 C3NCBI
cM Map133.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Erbb4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1551357
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.